Autologous adipose-derived stromal vascular fraction in patients with systemic sclerosis: 12-month follow-up

Rheumatology
Perrine Guillaume-JugnotBrigitte Granel

Abstract

Impaired hand function greatly contributes to disability and reduced quality of life in SSc patients. Autologous adipose-derived stromal vascular fraction (ADSVF) is recognized as an easily accessible source of regenerative cells. We reported positive 6-month safety and efficacy results from an open-label clinical trial assessing s.c. injection of autologous ADSVF into the fingers in SSc patients. The objective of this report is to describe the effects at 12 months. Twelve females, mean age 54.5 years (s.d. 10.3), were assessed 1 year after ADSVF injection. Patients were eligible if they had a Cochin Hand Function Scale score >20/90. ADSVF was obtained from lipoaspirate using an automated processing system and subsequently injected into the s.c. tissue of each finger in contact with neurovascular pedicles in a one-time procedure. Endpoints were changes in hand disability and skin fibrosis, vascular manifestations, pain and quality of life at the 12 month follow-up. During the visit, patients estimated the benefit of the procedure with a specific self-completed questionnaire. A significant decrease from baseline of 51.3% (P < 0.001) for Cochin Hand Function Scale score, 63.2% (P < 0.001) for RP severity and 46.8% (P = 0.001) for...Continue Reading

Associated Clinical Trials

References

Oct 2, 2002·Arthritis and Rheumatism·Peter A MerkelUNKNOWN Scleroderma Clinical Trials Consortium
Jan 17, 2009·Annals of the Rheumatic Diseases·O Kowal-BieleckaUNKNOWN EUSTAR Co-Authors
Apr 1, 2009·Arthritis and Rheumatism·Dinesh KhannaUNKNOWN Relaxin Investigators and the Scleroderma Clinical Trials Consortium

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Citations

Jul 17, 2016·Best Practice & Research. Clinical Rheumatology·Kathleen MorrisroeMandana Nikpour
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