Autologous adipose tissue‑derived mesenchymal stem cells are involved in rat liver regeneration following repeat partial hepatectomy

Molecular Medicine Reports
Tao LiuYuliang Wang

Abstract

Adipose tissue‑derived mesenchymal stem cells (ADSCs) have been considered to be attractive and readily available adult mesenchymal stem cells, and they are becoming increasingly popular for use in regenerative cell therapy, as they are readily accessible through minimally invasive techniques. The present study investigated whether autologous ADSC transplantation promoted liver regeneration following a repeat partial hepatectomy in rats. The rats were divided into three groups as follows: 70% partial hepatectomy (PH) group; repeat PH (R‑PH) group and R‑PH/ADSC group, subjected to R‑PH and treated with autologous ADSCs via portal vein injection. In each group, the rats were sacrificed at different time points postoperatively in order to evaluate the changes in liver function and to estimate the liver regenerative response. The expression of proliferating cell nuclear antigen (PCNA) labeling index in the liver was measured using immunohistochemistry. The expression levels of hepatocyte growth factor (HGF) mRNA were measured using reverse transcription polymerase chain reaction. The results showed that regeneration of the remaining liver following R‑PH was significantly promoted by ADSC transplantation, as shown by a significant i...Continue Reading

References

Jan 1, 1997·ILAR Journal·J. Derrell ClarkDennis F. Kohn
Oct 24, 2001·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Takeshi AokiMituo Kusano
Dec 12, 2003·Lancet·Josep M LlovetJordi Bruix
Mar 8, 2006·The Journal of Surgical Research·Shuji SaitoHiroshi Shimada
Nov 28, 2009·Current Stem Cell Research & Therapy·Tetsuya IshikawaTakahiro Ochiya
Jul 2, 2010·World Journal of Surgical Oncology·Yanming ZhouZhenyu Liu
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Ahmedin JemalDavid Forman
Sep 14, 2011·Laboratory Investigation; a Journal of Technical Methods and Pathology·Ange-Clarisse DusabinezaIsabelle A Leclercq
Feb 23, 2012·Lancet·Alejandro FornerJordi Bruix
Mar 16, 2013·The British Journal of Surgery·D A WichertsD Azoulay
Apr 26, 2013·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Dong-Liang LiJing-Jing Fan
May 10, 2013·ANZ Journal of Surgery·José G TralhãoFrancisco Castro-Sousa
Dec 7, 2013·World Journal of Gastroenterology : WJG·Matteo SerenariAntonio Daniele Pinna
Dec 7, 2013·Stem Cells International·Eva KoellenspergerUwe Leimer
Jan 24, 2014·Digestive Diseases and Sciences·Masaki KaiboriA-Hon Kwon
Jan 31, 2015·Molecular Medicine Reports·Long DingWeibin Xia

❮ Previous
Next ❯

Citations

May 1, 2019·Journal of Materials Science. Materials in Medicine·Yadong LiuWeiguo Zhang
Jul 10, 2019·Stem Cell Research & Therapy·Chenxia HuLanjuan Li
Jun 20, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Fernanda O BortolazzoAndrea A de Aro
Jul 11, 2019·Current Transplantation Reports·Aylin AcunBasak E Uygun

❮ Previous
Next ❯

Methods Mentioned

BETA
flow cytometry
serum collection

Software Mentioned

CellQuest
SPSS
Primer Premier

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.