Autologous bone marrow cell infusion therapy for liver cirrhosis patients

Journal of Hepato-biliary-pancreatic Sciences
Shuji Terai, Isao Sakaida

Abstract

We developed a novel cell therapy, autologous bone marrow cell infusion (ABMi) therapy, using autologous bone marrow, for liver cirrhosis patients. Our study depends on the findings from basic studies that bone marrow cell infusion repairs liver fibrosis in the cirrhotic liver, and improves liver function and the survival rate. Beginning in November 2003, we started a clinical study and found that ABMi therapy was safe and effective for liver cirrhosis patients. Multicenter trials in Japan and Korea have also shown the effectiveness of ABMi therapy. In this review, we report the current status of ABMi therapy for liver cirrhosis patients.

References

Jun 28, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·N D TheiseD S Krause
Aug 5, 2000·Nature·M R AlisonN A Wright
Feb 8, 2003·Journal of Gastroenterology·Shuji TeraiKiwamu Okita
Jan 7, 2004·Biochemical and Biophysical Research Communications·Naoki YamamotoKiwamu Okita
Nov 27, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Isao SakaidaKiwamu Okita
Dec 26, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Reiichi HigashiyamaIsao Okazaki
Mar 22, 2007·World Journal of Gastroenterology : WJG·Andre Castro LyraLuiz Guilherme Costa Lyra
Jul 31, 2007·World Journal of Gastroenterology : WJG·Mehdi MohamadnejadHossein Baharvand
Jan 7, 2009·Biochemical and Biophysical Research Communications·Shinya OhataHiroshi Nishina

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Citations

Feb 15, 2012·Journal of Gastroenterology and Hepatology·Masaki MaedaIsao Sakaida
Mar 1, 2012·World Journal of Gastroenterology : WJG·Tarek EzzatSteven W M Olde Damink
Jul 31, 2013·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Luiz Fernando QuintanilhaIsao Sakaida
Feb 7, 2013·Biochimica Et Biophysica Acta·Alison Mackinnon, Stuart Forbes

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