Autologous Bone Marrow Concentrates and Concentrated Growth Factors Accelerate Bone Regeneration After Enucleation of Mandibular Pathologic Lesions

The Journal of Craniofacial Surgery
Wael M TalaatOsama A Adly

Abstract

Stem cell therapy is a revolutionary new way to stimulate mesenchymal tissue regeneration. The platelets concentrate products started with platelet-rich plasma (PRP), followed by platelet-rich fibrin (PRF), whereas concentrated growth factors (CGF) are the latest generation of the platelets concentrate products which were found in 2011. The aim of the present study was to evaluate the potential of combining autologous bone marrow concentrates and CGF for treatment of bone defects resulting from enucleation of mandibular pathologic lesions. Twenty patients (13 males and 7 females) with mandibular benign unilateral lesions were included, and divided into 2 groups. Group I consisted of 10 patients who underwent enucleation of the lesions followed by grafting of the bony defects with autologous bone marrow concentrates and CGF. Group II consisted of 10 patients who underwent enucleation of the lesions without grafting (control). Radiographic examinations were done immediately postoperative, then at 1, 3, 6, and 12 months, to evaluate the reduction in size and changes in bone density at the bony defects. Results indicated a significant increase in bone density with respect to the baseline levels in both groups (P < 0.05). The increa...Continue Reading

References

Sep 12, 2000·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·M ChiapascoM Crescentini
Nov 19, 2003·Biochemical and Biophysical Research Communications·Hannu-Ville LeskeläPetri Lehenkari
Apr 28, 2004·The Journal of Craniofacial Surgery·Masaki YazawaNaohide Watanabe
Jul 5, 2005·The Journal of Bone and Joint Surgery. American Volume·Ph HernigouH Rouard
Mar 1, 2006·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·David M DohanBruno Gogly
Apr 3, 2007·Journal of Periodontology·Hesham El-SharkawyThomas E Van Dyke
Apr 18, 2007·Artificial Organs·Humberto Filho CerrutiMarcelo Cavenaghi Pereira da Silva
Dec 17, 2009·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Jun LeeEun-Cheol Kim
Jan 9, 2010·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Elisabetta CenniNicola Baldini
Mar 5, 2010·Journal of Dental Research·C GalliG M Macaluso
May 1, 2010·Physiology·Esther WitschYosef Yarden
Aug 27, 2010·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Marcus JägerRüdiger Krauspe
Jan 5, 2011·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Yi ZhaoYi-Ning Wang
Apr 8, 2011·The Journal of Bone and Joint Surgery. American Volume·Ippokratis HatzokosAnastasios Christodoulou
Jul 23, 2011·Microscopy Research and Technique·Luigi Fabrizio RodellaRita Rezzani
Aug 5, 2011·British Medical Bulletin·Shaul BeythMeir Liebergall
Nov 1, 2013·Molecular Medicine Reports·Bohan Yu, Zuolin Wang
Apr 29, 2014·Drug Discovery Today·Arun R ShrivatsJeffrey O Hollinger
Jun 5, 2015·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Siniga MirkovićTatjana Pugkar
Dec 30, 2016·The Journal of Craniofacial Surgery·Reiko SakioKazuo Kishi

❮ Previous
Next ❯

Citations

Jan 10, 2019·Journal of Clinical Periodontology·Siddharth ShanbhagKamal Mustafa
Aug 14, 2019·The Journal of Craniofacial Surgery·Wael M TalaatTarek F A Keshk
Aug 28, 2018·Clinical Oral Investigations·Min YuJing Qiao
Sep 1, 2020·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Emine AdalıSevtap Günbay

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Related Papers

Indian Journal of Dental Research : Official Publication of Indian Society for Dental Research
Vikas Sukhadeo MeshramManish Sevalal Tiwari
Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA
Yunus GuzelMahmut Nedim Doral
The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association
Hazem Shawky, Sameh Ahmed Seifeldin
© 2022 Meta ULC. All rights reserved