Autologous bone marrow-derived mononuclear cell therapy in Chinese patients with critical limb ischemia due to thromboangiitis obliterans: 10-year results

Stem Cell Research & Therapy
Jianming GuoYongquan Gu

Abstract

For patients with thromboangiitis obliterans (TAO), revascularization with bypass or angioplasty is frequently not feasible due to the poor outflow of the distal small vessels. We evaluated the long-term results of our experience treating patients with TAO with autologous bone marrow-derived mononuclear cells (ABMMNCs) to determine the safety and efficacy of ABMMNC therapy in patients with critical limb ischemia due to TAO. This was a retrospective chart review from a single university hospital vascular surgery center between January 2005 and July 2006. Patients were treated with smoking cessation and either aspirin (100 mg/day) alone or aspirin and ABMMNC injection according to patient preference. Groups were compared for demographics, clinical characteristics, and short-term and long-term results. Of 59 patients with TAO who were treated, 19 patients elected aspirin alone and 40 patients elected aspirin and ABMMNC injection. No patients suffered perioperative complications and 49 (83%) patients remained smoke-free for 10 years. The 10-year amputation-free survival was 85.3% (29/34) in patients treated with ABMMNCs compared to 40% (6/15) in patients treated with aspirin alone (p = 0.0019). Ulcer area (p < 0.0001), toe-brachial...Continue Reading

References

Oct 6, 1997·Journal of Vascular Surgery·R B RutherfordD N Jones
Feb 10, 1999·International Journal of Cardiology·K Tanaka
Sep 21, 2000·The New England Journal of Medicine·J W Olin
Sep 21, 2002·Lancet·Eriko Tateishi-YuyamaUNKNOWN Therapeutic Angiogenesis using Cell Transplantation (TACT) Study Investigators
Jan 14, 2004·Journal of Vascular Surgery·Takashi OhtaIkuo Sugimoto
Oct 16, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Koji YamamotoToyoaki Murohara
May 26, 2006·Orphanet Journal of Rare Diseases·Perttu E T Arkkila
Jan 31, 2012·Annals of Vascular Surgery·Lanfroi GrazianiSandra Sigala
Mar 6, 2012·Vascular Pharmacology·Katharina S VolzJohn P Cooke
Dec 4, 2013·Methodist DeBakey Cardiovascular Journal·Crystal M BothamJohn P Cooke
May 2, 2014·The Korean Journal of Thoracic and Cardiovascular Surgery·Hee Jae Jun
Mar 5, 2015·Acta Biochimica Et Biophysica Sinica·Lanfang LiZhisheng Jiang
Mar 30, 2016·Journal of Vascular Surgery·Tiffany W LiangMichael P Murphy

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Citations

Mar 7, 2020·Circulation Journal : Official Journal of the Japanese Circulation Society·Farina Mohamad YusoffYukihito Higashi
Mar 17, 2020·Circulation Journal : Official Journal of the Japanese Circulation Society·Rei ShibataToyoaki Murohara
Dec 29, 2020·Frontiers in Cell and Developmental Biology·Marta Rojas-TorresMª Carmen Durán-Ruiz
Mar 4, 2021·International Journal of Molecular Sciences·Lucía Beltrán-CamachoMᵃ Carmen Durán-Ruiz

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Methods Mentioned

BETA
amputation
amputations

Software Mentioned

SPSS
Graphpad Prism

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