Autologous bone marrow stem cell transplantation via the hepatic artery for the treatment of hepatitis B virus-related cirrhosis: a PRISMA-compliant meta-analysis based on the Chinese population.

Stem Cell Research & Therapy
Ani SunTing Xiao

Abstract

Autologous bone marrow stem cell (ABMSC) transplantation has been considered a promising option for hepatitis B virus-related cirrhosis (HBV-C). Although an analysis of the published literature has been performed, the exact effects and safety have yet to be systematically investigated. We conducted a wide-ranging online search of electronic databases (Web of Science, PubMed, Cochrane Library, Embase, CNKI, VIP, and Wanfang database) to reach systematic conclusions. Outcome measurements, including therapeutic efficacy, clinical symptoms, and adverse events, were extracted and analyzed statistically. Ultimately, a total of 10 articles including 662 HBV-C patients were included in this analysis, which indicated that ABMSC therapy could significantly improve liver function in patients with HBV-C in terms of the MELD and Child-Pugh scores, total bilirubin, serum albumin, alanine aminotransferase, aspartate aminotransferase, and coagulation function. Compared with patients receiving routine therapy (RT), those treated with ABMSC and RT combined therapy showed improved clinical symptoms, as represented by increased appetite and reduced fatigue and ascitic fluid and abdominal distension. Moreover, the fibrosis indexes indicated a reduc...Continue Reading

References

May 21, 2009·European Journal of Gastroenterology & Hepatology·Pedram KharazihaMasoud Soleimani
May 25, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Liang PengZhi-liang Gao
Mar 23, 2012·Journal of Hepatology·UNKNOWN European Association For The Study Of The Liver
Jul 6, 2012·Statistics in Medicine·Dan JacksonRichard D Riley
Jun 11, 2014·World Journal of Gastroenterology : WJG·En-Qiang Chen, Hong Tang
Sep 23, 2014·World Journal of Methodology·Takafumi SaitoYoshiyuki Ueno
Jun 26, 2015·World Journal of Gastroenterology : WJG·Mithun SharmaD Nageshwar Reddy
Oct 1, 2015·World Journal of Gastroenterology : WJG·Young Woo EomSoon Koo Baik
Dec 23, 2015·Expert Review of Gastroenterology & Hepatology·Toshihiko MatsumotoIsao Sakaida
Jun 25, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ki Tae SukSoon Koo Baik
Aug 26, 2016·Acta Neurologica Scandinavica·A KumarA Gulati
Jan 5, 2017·Liver International : Official Journal of the International Association for the Study of the Liver·Guo-Feng ChenGeorge Lau
Jul 29, 2017·Expert Review of Gastroenterology & Hepatology·Masako OkadaMindie H Nguyen
Dec 12, 2017·Journal of Clinical and Translational Hepatology·Jinlin HouUNKNOWN Chinese Society of Infectious Diseases, Chinese Medical Association

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