PMID: 2114212Aug 1, 1990Paper

Autologous bone marrow transplantation and factor XII, factor VII, and protein C deficiencies. Report of a new association and its possible relationship to endothelial cell injury

Cancer
P A KaufmanW P Peters

Abstract

Four patients who underwent treatment with high-dose chemotherapy (HDC) and autologous bone marrow transplantation (ABMT) and in whom posttreatment deficiencies of Factor XII and protein C subsequently developed are reported. Factor VII or Factor X deficiencies also developed in several of these patients. Three of these patients experienced chemotherapy-related cardiac, hepatic, or pulmonary toxicity. It is believed by many that endothelial cell injury may be the underlying lesion responsible for these various organ system toxicities seen in the setting of ABMT, although direct evidence of this is lacking. It is proposed that the factor deficiencies described in this report may be an additional consequence of endothelial cell injury or dysfunction. These coagulation factor deficiencies may therefore serve as both a marker to follow these organ system toxicities with and as a useful tool to better study and understand the mechanisms underlying these events. Additionally, deficiencies of either Factor VII or Factor X developed in several patients that were of a sufficient magnitude such that factor replacement therapy would be indicated before any invasive procedures or in the event of significant hemorrhage.

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Citations

Apr 15, 2003·Neurologic Clinics·Hendrikus G J Krouwer, Eelco F M Wijdicks
Mar 4, 2009·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Samuel DouillardThierry Patrice
Feb 12, 1999·Australian Dental Journal·J C ChengB S Yan
Dec 23, 2015·Bone Marrow Transplantation·S ChaturvediB N Savani
Jul 17, 2008·Journal of Thrombosis and Haemostasis : JTH·A GonsalvesD S Allan
Dec 12, 1997·American Journal of Hematology·T MoriY Ikeda
Jan 16, 2016·Therapeutic Advances in Gastroenterology·Muhammad Wasif SaifRobert B Diasio
Mar 29, 2002·Bone Marrow Transplantation·A A ToorN S Key
Nov 15, 2005·Bone Marrow Transplantation·M A BarronS Zlotkin
Jun 26, 2020·European Respiratory Review : an Official Journal of the European Respiratory Society·Samran HaiderAyman O Soubani

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