Autologous cells derived from different sources and administered using different regimens for 'no-option' critical lower limb ischaemia patients

The Cochrane Database of Systematic Reviews
S Fadilah Abdul WahidNai Ming Lai

Abstract

Revascularisation is the gold standard therapy for patients with critical limb ischaemia (CLI). In over 30% of patients who are not suitable for or have failed previous revascularisation therapy (the 'no-option' CLI patients), limb amputation is eventually unavoidable. Preliminary studies have reported encouraging outcomes with autologous cell-based therapy for the treatment of CLI in these 'no-option' patients. However, studies comparing the angiogenic potency and clinical effects of autologous cells derived from different sources have yielded limited data. Data regarding cell doses and routes of administration are also limited. To compare the efficacy and safety of autologous cells derived from different sources, prepared using different protocols, administered at different doses, and delivered via different routes for the treatment of 'no-option' CLI patients. The Cochrane Vascular Information Specialist (CIS) searched the Cochrane Vascular Specialised Register, the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE Ovid, Embase Ovid, the Cumulative Index to Nursing and Allied Health Literature (CINAHL), the Allied and Complementary Medicine Database (AMED), and trials registries (16 May 2018). Review authors ...Continue Reading

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Citations

Mar 20, 2019·International Journal of Molecular Sciences·Carmela Dell'AversanaGilda Cobellis
Jun 27, 2019·International Journal of Molecular Sciences·Maria A BoldyrevaYelena V Parfyonova
Aug 17, 2019·Frontiers in Immunology·Henry CaplanCharles S Cox
Dec 20, 2019·The Cochrane Database of Systematic Reviews·S Fadilah Abdul WahidNai Ming Lai

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