Autologous chondrocyte implantation in children and adolescents.

Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA
Hagen SchmalPhilipp Niemeyer

Abstract

Autologous chondrocyte implantation (ACI) is a well-established treatment method for cartilage defects in knees. Age-related grouping was based on expression data of cartilage-specific markers. Specificities of ACI in the different populations were analysed. Two hundred and sixty-seven patients undergoing ACI in the knee between 2006 and 2010 were included in this analysis. Cell characteristics and expression data of cartilage-specific surface markers as CD44, aggrecan and collagen type II were statistically analysed for age association. Epidemiological data of the defined groups were compared. Course of treatment was evaluated using MRI. A correlation analysis showed statistically significant associations between age and aggrecan or collagen type II expression in all patients <30 years. A cluster analysis could predict age-dependent expression of these markers separating groups with an average age of 18.1 ± 2.3 and 23.6 ± 4.2 years, respectively (p < 0.02). Discriminance analysis suggested the age border between adults and juveniles at about 20 years. There was no influence of age on cell characteristics or CD44 expression. In the 19 of 267 patients with an age ≤18 years, gender distribution was not different compared to adult...Continue Reading

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Citations

Apr 5, 2014·Clinics in Sports Medicine·John D Polousky, Jay Albright
Oct 22, 2013·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Hagen SchmalPhilipp Niemeyer
May 11, 2016·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Alex C DiBartolaDavid C Flanigan
Jan 28, 2017·The American Journal of Sports Medicine·Takahiro OguraTom Minas
Sep 4, 2013·Regenerative Medicine·Benjamin M DaviesAndrew Carr

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