Abstract
Postmastectomy pain syndrome (PMPS) represents a common complication following breast surgery defined as a chronic neuropathic pain located in the front of the chest, in the axilla and in the upper arm that for more than 3 months after surgery. Several medications prove to be ineffective while autologous fat grafting revealed to be an innovative solution in the treatment of neuropathic pain syndromes based on retrospective studies. For this reason, we performed a prospective multicenter trial to reduce the memory bias and further increase the evidence of the results. From February 2018 to March 2019, 37 female patients aged between 18 and 80 years, underwent mastectomy or quadrantectomy with pathologic scarring and chronic persistent neuropathic pain, compatible with PMPS, are been included in the study and treated with autologous fat grafting. During the enrollment phase, patients were asked to estimate pain using the Visual Analogue Scale (VAS) and POSAS questionnaire in order to evaluate scar outcomes. The VAS scale, starting from 6.9 (1.3), decreased in the first month by 3.10 (1.59), continuing to fall by 0.83 (1.60) to 3 months and by 0.39 (2.09) at 6 months. Statistical analysis showed a significant reduction after 1 mon...Continue Reading
References
Dec 1, 1992·Pain·Peter N C Watson, Ramon J Evans
Feb 1, 1996·Pain·Kalso EijaNeuvonen Pertti J
Mar 13, 2002·European Journal of Pain : EJP·Tiina TasmuthEija Kalso
Oct 10, 2006·Vitamins and Hormones·John N Fain
Dec 7, 2006·Cytotherapy·K Le Blanc
Apr 7, 2007·Plastic and Reconstructive Surgery·Gino RigottiAndrea Sbarbati
Aug 22, 2007·Cell Transplantation·Kirsten A KeyserHans-Peter Kiem
Feb 29, 2008·Aesthetic Plastic Surgery·M KlingerM Torre
Apr 26, 2008·European Journal of Heart Failure·Manuel MazoFelipe Prósper
Jun 21, 2008·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·O J VilholmS H Sindrup
Jul 1, 2008·The Journal of Pain : Official Journal of the American Pain Society·Monique A SteegersOliver H Wilder-Smith
Oct 22, 2009·Anesthesia and Analgesia·Israel Z YardeniHanna Bessler
Dec 3, 2010·Plastic and Reconstructive Surgery·Hirotaka SugaKotaro Yoshimura
Jul 27, 2011·Plastic and Reconstructive Surgery·Fabio CaviggioliMarco Klinger
Oct 26, 2012·Headache·Paolo GaetaniGiovanni Broggi
Apr 26, 2014·Aesthetic Plastic Surgery·Luca MaioneMarco Klinger
Jan 22, 2015·Cell Transplantation·Nicoletta Del PapaMarco Klinger
Jun 6, 2015·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Steven PikeYuan Liu
Feb 10, 2016·Stem Cells International·Fabio CaviggioliMarco Klinger
Jan 6, 2017·Journal of breast cancer·Alexander Andersen JuhlTine Engberg Damsgaard
Jun 9, 2017·Aesthetic Plastic Surgery·Marco KlingerLuca Maione
Sep 28, 2017·Journal of the National Cancer Institute
Dec 20, 2017·Plastic and Reconstructive Surgery·Junrong CaiFeng Lu
Jan 6, 2018·Orbit·Francesco KlingerAlessandra Di Maria
Jul 4, 2018·The Journal of Pain : Official Journal of the American Pain Society·Raymond C TaitChristopher Herndon
Mar 2, 2019·Aesthetic Plastic Surgery·Alp ErcanOguz Cetinkale
Nov 20, 2019·Clinics in Plastic Surgery·Marco KlingerValeriano Vinci
Citations
Sep 11, 2020·The Breast Journal·Domenico CostanzoValeriano Vinci
Apr 15, 2021·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Andrea RimondoFrancesco Klinger
Apr 23, 2021·Aesthetic Plastic Surgery·Rong HuangZhiguo Su
Apr 24, 2021·Aesthetic Plastic Surgery·Andrea BattistiniFrancesco Klinger
Apr 28, 2021·Aesthetic Plastic Surgery·Andrea BattistiniValeriano Vinci
May 29, 2021·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·Andrea BattistiniFrancesco Klinger
May 31, 2021·Clinical Breast Cancer·Andrea LisaMarco Klinger
Jul 14, 2021·Aesthetic Plastic Surgery·Fabio CaviggioliValeriano Vinci
Aug 12, 2021·Aesthetic Plastic Surgery·Klinger FrancescoVinci Valeriano
Jul 30, 2021·Aesthetic Surgery Journal·Fabio CaviggioliValeriano Vinci
Sep 2, 2021·Plastic and Reconstructive Surgery·Yujie ChenGuangxue Li
Sep 2, 2021·Plastic and Reconstructive Surgery·Andrea LisaFabio Caviggioli
Oct 5, 2021·Plastic and Reconstructive Surgery·Andrea BattistiniFrancesco Klinger
Oct 5, 2021·Aesthetic Surgery Journal·Summer E Hanson
Jan 26, 2022·Plastic and Reconstructive Surgery·Martin SollieJens Ahm Sørensen