Autologous fat transplantation alters gene expression patterns related to inflammation and hypoxia in the irradiated human breast

The British Journal of Surgery
A LindegrenM Halle

Abstract

Radiation-induced fibrosis, an adverse effect of breast cancer treatment, is associated with functional and cosmetic impairment as well as surgical complications. Clinical reports suggest improvement following autologous fat transplantation, but the mechanisms underlying this effect are unknown. A global gene expression analysis was undertaken to identify genetic pathways dysregulated by radiation and evaluate the impact of autologous fat transplantation on gene expression. Adipose tissue biopsies were taken synchronously from irradiated and contralateral non-irradiated breasts, before and 1 year after autologous fat transplantation. Whole-genome gene expression analyses were performed, and Hallmark gene set analysis used to explore the effect of radiotherapy and autologous fat transplantation on gene expression. Forty microarrays were analysed, using bilateral biopsies taken from ten patients before and after autologous fat transplantation. Forty-five pathways were identified among the 3000 most dysregulated transcripts after radiotherapy in irradiated compared with non-irradiated breast (P ≤ 0·023; false discovery rate (FDR) no higher than 0·026). After autologous fat transplantation, 575 of the 3000 genes were again altered....Continue Reading

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Citations

Aug 17, 2019·Pharmacology & Therapeutics·Asim EjazPeter J Rubin
Dec 21, 2020·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Xinyu ZhangFacheng Li

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