Autologous liquid platelet rich fibrin: A novel drug delivery system

Acta Biomaterialia
Richard J Miron, Yufeng Zhang

Abstract

There is currently widespread interest within the biomaterial field to locally deliver biomolecules for bone and cartilage regeneration. Substantial work to date has focused on the potential role of these biomolecules during the healing process, and the carrier system utilized is a key factor in their effectiveness. Platelet rich fibrin (PRF) is a naturally derived fibrin scaffold that is easily obtained from peripheral blood following centrifugation. Slower centrifugation speeds have led to the commercialization of a liquid formulation (liquid-PRF) resulting in an upper plasma layer composed of liquid fibrinogen/thrombin prior to clot formation that remains in its liquid phase for approximately 15 min until injected into bodily tissues. Herein, we introduce the use of liquid PRF as an advanced local delivery system for small and large biomolecules. Potential target molecules including large (growth factors/cytokines and morphogenetic/angiogenic factors), as well as small (antibiotics, peptides, gene therapy and anti-osteoporotic) molecules are considered potential candidates for enhanced bone/cartilage tissue regeneration. Furthermore, liquid-PRF is introduced as a potential carrier system for various cell types and nano-sized...Continue Reading

Citations

Aug 11, 2018·Journal of Tissue Engineering and Regenerative Medicine·Yong-Can HuangKeith D K Luk
Jan 11, 2019·Journal of Clinical Periodontology·David PolakLior Shapira
Aug 27, 2019·Journal of Biomedical Materials Research. Part a·Jinglun ZhangYufeng Zhang
Apr 10, 2019·International Journal of Molecular Sciences·Silvia BarbonRaffaele De Caro
Aug 6, 2020·Bioengineering·Tomoyuki KawaseCarlos Fernando Mourão
Mar 30, 2021·Open Medicine·Voja PavlovicPredrag Stojanovic
Apr 13, 2021·Frontiers in Bioengineering and Biotechnology·Xia ZhaoAravind Athiviraham
May 25, 2021·Bioengineering & Translational Medicine·Sijing JiangJiacai He
Aug 8, 2021·International Journal of Molecular Sciences·Zahra KargarpourReinhard Gruber
Oct 14, 2019·ACS Biomaterials Science & Engineering·Hui ChiJinglong Yan
Dec 9, 2019·ACS Biomaterials Science & Engineering·Lin ZhangShufang Wang

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