Autologous melanoma cell vaccine using monocyte-derived dendritic cells (NBS20/eltrapuldencel-T)

Future Oncology
Asad JavedTakami Sato

Abstract

Targeted therapy and immunotherapy have revolutionized the treatment of advanced melanoma. Despite recent advances, lack of long-term efficacy from targeted therapy and serious immune-related toxicity are major concerns. There is unmet need for 'durable' and 'safe' treatment options for advanced melanoma. Cancer vaccine therapy in melanoma has been investigated for many years with modest clinical efficacy. More recently, dendritic cell-based vaccine products have become available for clinical use and have been the focus of investigation. CLBS20 (NBS20/eltrapuldencel-T) is a novel dendritic cell-based vaccine product that has shown promising results in early phase trials in advanced melanoma. This cancer vaccine approach could play an important role in providing a sustainable survival benefit, targeting cancer cells themselves and avoiding off-target immune-related toxicity.

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Oct 21, 2016·Immunological Investigations·Behjatolah Monzavi-KarbassiThomas Kieber-Emmons
Sep 22, 2017·International Reviews of Immunology·Carolina SchäferLeandro J Carreño
Dec 1, 2016·Melanoma Management·Robert O DillmanAndrew N Cornforth
Jul 17, 2020·Journal of Immunology Research·Massimo RalliAntonio Greco

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Datasets Mentioned

BETA
GM-CSF

Methods Mentioned

BETA
leukapheresis
surgical resection

Clinical Trials Mentioned

NCT01875653
NCT01042535
NCT00012064
NCT00436930

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