Autologous nanofat transplantation accelerates foot wound healing in diabetic rats

Regenerative Medicine
Li ChenXuan Yang

Abstract

Aim: This study explored the effects of local transplantation of autologous nanofat in the treatment of rats with diabetic foot wounds. Materials & methods: Nanofat was transplanted into the left foot wound of diabetic rats. Phosphate-buffered saline injection in the right served as control. We measured wound size, the extent of epithelization, microvessel density and the expression levels of cytokines at six different time-points postoperation. Results: Compared with the control feet, nanofat-treated feet had significantly smaller wound areas at 7 and 9 days after grafting and showed better re-epithelialization, a greater number of microvessels and higher levels of angiogenic factor expression. Conclusion: This research shows that autologous nanofat transplantation can promote diabetic foot wound healing in rats.

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Citations

Aug 10, 2019·Current Opinion in Organ Transplantation·Huseyin KaragozVijay S Gorantla
Dec 20, 2019·Annals of Plastic Surgery·Ruobing AnWeigang Cao
May 16, 2021·Journal of Tissue Engineering and Regenerative Medicine·Arvind Manikantan PadmaMats Hellström

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Methods Mentioned

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amputation
scanning electron microscopy
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Immunoprecipitation
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