PMID: 3773495Oct 1, 1986Paper

Autologous pericardium versus a xenograft substitute in myocardial wound healing

The Journal of Surgical Research
R G CohenD C Miller

Abstract

This study compared repair of myocardial wounds covered with autologous pericardium to healing of wounds covered with glutaraldehyde-preserved bovine pericardium in an experimental canine model. Right (RV) and left (LV) full thickness ventriculotomies were made and closed. In the control group (n = 12), the pericardium was closed over the wound; in the experimental group (n = 12), wounds were covered with bovine pericardium. Animals were sacrificed at 14, 21, 28, and 42 days. After excising the pericardium, 6 mm punch biopsies of normal RV, RV wound, normal LV, and LV wound were assayed for hydroxyproline (HPro). Both autologous and bovine pericardium became densely adherent to the wounds. Bovine pericardium was mildly adherent over unwounded areas, while autologous pericardium was usually free. Normal RV contained more than twice as much HPro as normal LV (5.4 +/- 0.57 micrograms/mg vs 1.7 +/- 0.35 micrograms/mg, P less than 0.0002). A gradual rise in HPro over time was seen in both groups, but this increase was statistically significant only at 42 days (P less than 0.05). There was no significant difference in HPro between wounds covered with autologous pericardium and those covered with bovine grafts (P = 0.13) at any of the...Continue Reading

References

Nov 1, 1977·Cardiovascular Research·P G CaspariP Harris
Jun 1, 1978·Chest·M C FishbeinP R Maroko
Jan 1, 1976·The Annals of Thoracic Surgery·F G SchechterL R Bryant
Nov 1, 1964·Journal of Clinical Pathology·R A GRANT

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Citations

Jul 30, 2010·Clinical Oral Implants Research·M V F AraújoJ E Davies

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