Abstract
This study aimed to evaluate, histomorphometrically, the use of periodontal ligament cells (PDL cells) in the treatment of class III furcation defects. PDL cells were obtained from the mandibular tooth extracted from each dog (7), cultured in vitro and phenotypically characterized. Bilateral class III furcation defects were created at mandibular 3rd and 4th premolars and were randomly assigned to: coronally positioned flap, GTR Group: GTR, Sponge Group: carrier + GTR, Cell Group: carrier + PDL cells + GTR. After 3 months of healing, data analysis demonstrated that the Cell Group presented a superior length of new cementum (4.82 ± 0.61 mm; 3.66 ± 0.95 mm; 2.87 ± 0.74 mm and 1.70 ± 0.60 mm, p < 0.001), a greater extension of periodontal regeneration (3.43 ± 1.44 mm; 2.33 ± 0.95 mm; 1.52 ± 0.39 mm and 0.69 ± 0.59 mm, p = 0.001) and a larger area of new bone (5.45 ± 1.58 mm(2) ; 3.94 ± 1.52 mm(2) ; 2.91 ± 0.56 mm(2) and 1.89 ± 0.95 mm(2) , p = 0.0012), when compared with Sponge, GTR and CONTROL GROUP, respectively. The PDL cells in association with GTR may significantly promote periodontal regeneration in class III furcation defects surgically created in dogs.
References
May 1, 1976·Journal of Periodontology·A H Melcher
Jan 1, 1992·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·J B Lian, G S Stein
Nov 1, 1991·Journal of Clinical Periodontology·W Beertsen
Aug 1, 1991·Journal of Periodontology·N ArceoM J Somerman
Mar 1, 1991·Journal of Clinical Periodontology·L J van DijkH J Busscher
Jan 1, 1990·Archives of Oral Biology·M J SomermanJ J Sauk
Mar 1, 1989·Journal of Clinical Periodontology·R PontorieroF Sanavi
Oct 1, 1986·Journal of Clinical Periodontology·I AukhilE Pettersson
Jan 1, 1987·Journal of Clinical Periodontology·P PayotG Cimasoni
Oct 1, 1985·Journal of Clinical Periodontology·F IsidorJ Lindhe
Sep 1, 1984·Journal of Clinical Periodontology·J GottlowJ Lindhe
Dec 1, 1994·Journal of Periodontology·U M WikesjöG J Zimmerman
Jul 1, 1996·Journal of Periodontal Research·R M NohutcuM J Somerman
Apr 1, 1996·Journal of Periodontal Research·P M Bartold, A Raben
Feb 18, 1998·Journal of Dental Research·H LangR Nolden
Aug 29, 1998·Journal of Clinical Periodontology·P EickholzR Holle
Jun 6, 2000·Advanced Drug Delivery Reviews·A I CaplanS E Haynesworth
Jun 27, 2000·Journal of Cellular Physiology·M MizunoY Kuboki
Jun 29, 2000·Journal of Periodontology·C RossaJ C Fogo
May 29, 2002·Tissue Engineering·Altan DoganTülin Oygür
Apr 8, 2004·Journal of Periodontology·Chang-Sung KimChong-Kwan Kim
May 29, 2004·Tissue Engineering·Taka NakaharaYasuhiko Shimizu
Jul 13, 2004·Lancet·Byoung-Moo SeoSongtao Shi
Apr 28, 2005·Journal of Periodontal Research·Tatsuya AkizukiIsao Ishikawa
Sep 27, 2005·Journal of Dental Research·B-M SeoS Shi
Nov 26, 2005·Brazilian Oral Research·José Marcos Alves FernandesJoni Augusto Cirelli
Mar 4, 2006·Journal of Periodontology·Virgílio M RorizMárcio F M Grisi
Jun 1, 2006·Journal of Periodontology·Patricia F GonçalvesFrancisco H Nociti
Jul 19, 2006·Biomedical Research·Yoshinori MuranoSatoru Yamada
Feb 2, 2008·Stem Cells·Yi LiuSonglin Wang
Feb 10, 2009·Biomaterials·Takanori IwataIsao Ishikawa
Feb 14, 2009·Journal of Bone and Mineral Metabolism·Toru HiragaHiroaki Nakamura
Nov 19, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Ines ValentaPhilipp A Kaufmann
Jun 16, 2010·Journal of Clinical Periodontology·Philippe GaultTilmann Wurtz
Mar 12, 2011·Journal of Clinical Periodontology·Fabricia Ferreira SuaidEnilson Antônio Sallum
Citations
Nov 8, 2014·TheScientificWorldJournal·Maurizio BossùAntonella Polimeni
Apr 14, 2015·Periodontology 2000·Mariano SanzSøren Jepsen
Oct 3, 2015·Dental Clinics of North America·Joseph J Zambon
Jun 15, 2012·Biomaterials·Fa-Ming ChenQing Yu
Feb 26, 2013·Journal of Clinical Periodontology·Jenn-Rong YangKuo Yuan
Jun 27, 2014·Journal of Periodontal Research·R BrightP M Bartold
May 2, 2015·Tissue Engineering. Part B, Reviews·Xiang-Zhen YanJeroen J J P van den Beucken
Mar 11, 2016·Journal of Periodontology·Bruna R AmorimFrancisco H Nociti
Sep 27, 2014·Carbohydrate Polymers·Shengqi ZangQintao Wang
Jun 25, 2015·Stem Cells International·Murali RamamoorthiSimon D Tran
Apr 20, 2014·Stem Cells Translational Medicine·Paul MonsarratPhilippe Kémoun
Apr 11, 2017·Journal of Periodontal Research·S A TassiC C Villar
May 29, 2015·Journal of Applied Oral Science : Revista FOB·Mayra Laino AlbieroKarina Gonzales Silvério
May 29, 2015·Journal of Applied Oral Science : Revista FOB·Luciana Bastos AlvesDaniela Bazan Palioto
Mar 23, 2018·International Journal of Molecular Sciences·Beatriz Hernández-MonjarazVíctor Manuel Mendoza-Núñez
Dec 31, 2017·Journal of Clinical Periodontology·Javier NuñezMariano Sanz
Aug 11, 2017·Tissue Engineering. Part C, Methods·Karim M Fawzy El-Sayed, Christof E Dörfer
Mar 21, 2019·Periodontology 2000·Enilson A SallumAntonio W Sallum
Mar 21, 2019·Periodontology 2000·Javier NuñezMariano Sanz
Feb 23, 2019·Journal of Cellular Physiology·Mudasir Bashir GugjooGutulla Taru Sharma
Sep 13, 2019·Dental Materials Journal·Sophie PortronXavier Struillou
Sep 11, 2020·Stem Cells International·Beatriz Hernández-MonjarazVíctor Manuel Mendoza-Núñez
May 5, 2018·Tissue Engineering. Part B, Reviews·Valérie OrtiIvan Panayotov
Jun 6, 2019·Clinical Oral Investigations·Oliver LaugischAnton Sculean
Sep 6, 2019·Journal of Periodontal & Implant Science·Seung-Yoon YooChang-Sung Kim
Oct 4, 2020·Stem Cell Research & Therapy·Qiang LiYongbin Mou
Jul 13, 2021·World Journal of Stem Cells·Aline QueirozMarinella Holzhausen