Autologous periodontal ligament cells in the treatment of Class III furcation defects: a study in dogs

Journal of Clinical Periodontology
Fabricia Ferreira SuaidEnilson Antônio Sallum

Abstract

This study aimed to evaluate, histomorphometrically, the use of periodontal ligament cells (PDL cells) in the treatment of class III furcation defects. PDL cells were obtained from the mandibular tooth extracted from each dog (7), cultured in vitro and phenotypically characterized. Bilateral class III furcation defects were created at mandibular 3rd and 4th premolars and were randomly assigned to: coronally positioned flap, GTR Group: GTR, Sponge Group: carrier + GTR, Cell Group: carrier + PDL cells + GTR. After 3 months of healing, data analysis demonstrated that the Cell Group presented a superior length of new cementum (4.82 ± 0.61 mm; 3.66 ± 0.95 mm; 2.87 ± 0.74 mm and 1.70 ± 0.60 mm, p < 0.001), a greater extension of periodontal regeneration (3.43 ± 1.44 mm; 2.33 ± 0.95 mm; 1.52 ± 0.39 mm and 0.69 ± 0.59 mm, p = 0.001) and a larger area of new bone (5.45 ± 1.58 mm(2) ; 3.94 ± 1.52 mm(2) ; 2.91 ± 0.56 mm(2) and 1.89 ± 0.95 mm(2) , p = 0.0012), when compared with Sponge, GTR and CONTROL GROUP, respectively. The PDL cells in association with GTR may significantly promote periodontal regeneration in class III furcation defects surgically created in dogs.

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Mar 12, 2011·Journal of Clinical Periodontology·Fabricia Ferreira SuaidEnilson Antônio Sallum

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Citations

Nov 8, 2014·TheScientificWorldJournal·Maurizio BossùAntonella Polimeni
Apr 14, 2015·Periodontology 2000·Mariano SanzSøren Jepsen
Oct 3, 2015·Dental Clinics of North America·Joseph J Zambon
Jun 15, 2012·Biomaterials·Fa-Ming ChenQing Yu
Mar 11, 2016·Journal of Periodontology·Bruna R AmorimFrancisco H Nociti
Apr 20, 2014·Stem Cells Translational Medicine·Paul MonsarratPhilippe Kémoun
Apr 11, 2017·Journal of Periodontal Research·S A TassiC C Villar
May 29, 2015·Journal of Applied Oral Science : Revista FOB·Mayra Laino AlbieroKarina Gonzales Silvério
May 29, 2015·Journal of Applied Oral Science : Revista FOB·Luciana Bastos AlvesDaniela Bazan Palioto
Mar 23, 2018·International Journal of Molecular Sciences·Beatriz Hernández-MonjarazVíctor Manuel Mendoza-Núñez
Aug 11, 2017·Tissue Engineering. Part C, Methods·Karim M Fawzy El-Sayed, Christof E Dörfer
Mar 21, 2019·Periodontology 2000·Enilson A SallumAntonio W Sallum
Mar 21, 2019·Periodontology 2000·Javier NuñezMariano Sanz
Feb 23, 2019·Journal of Cellular Physiology·Mudasir Bashir GugjooGutulla Taru Sharma
Sep 11, 2020·Stem Cells International·Beatriz Hernández-MonjarazVíctor Manuel Mendoza-Núñez
May 5, 2018·Tissue Engineering. Part B, Reviews·Valérie OrtiIvan Panayotov
Jun 6, 2019·Clinical Oral Investigations·Oliver LaugischAnton Sculean
Jul 13, 2021·World Journal of Stem Cells·Aline QueirozMarinella Holzhausen

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