Autologous peripheral blood stem cell transplantation in children with refractory or relapsed lymphoma: results of Children's Oncology Group study A5962

Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Richard E HarrisMitchell S Cairo

Abstract

This prospective study was designed to determine the safety and efficacy of cyclophosphamide, BCNU, and etoposide (CBV) conditioning and autologous peripheral blood stem cell transplant (PBSCT) in children with relapsed or refractory Hodgkin and non-Hodgkin lymphoma (HL and NHL). Patients achieving complete remission (CR) or partial remission (PR) after 2 to 4 courses of reinduction underwent a granulocyte-colony stimulating factor (G-CSF) mobilized PBSC apheresis with a target collection dose of 5 × 10⁶ CD34(+)/kg. Those eligible to proceed received autologous PBSCT after CBV (7200 mg/m², 450-300 mg/m², 2400 mg/m²). Forty-three of 69 patients (30/39 HL, 13/30 NHL) achieved a CR/PR after reinduction. Thirty-eight patients (28 HL, 10 NHL) underwent PBSCT. All initial 6 patients who received BCNU at 450 mg/m² experienced grade III or IV pulmonary toxicity compared to none of the subsequent 32 receiving 300 mg/m² (P < .0001). The probability of overall survival (OS) at 3 years for all patients is 51% and for transplanted patients is 64%. The 3-year event-free survival (EFS) is 38% (45% for HL; 30% NHL). The 3-year EFS in transplanted patients is 66% (65% HL; 70% NHL). Initial duration of remission of ≥12 versus <12 months was asso...Continue Reading

References

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Citations

Jun 20, 2013·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Alan Davidson, Marc Hendricks
Jun 1, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Suzanne L WoldenJames Nachman
May 29, 2014·Expert Review of Respiratory Medicine·Maureen B Josephson, Samuel Brian Goldfarb
Feb 8, 2014·Pediatric Blood & Cancer·Paul D Harker-MurrayPeter David Cole
Mar 6, 2012·Pediatric Blood & Cancer·Marta PillonNHL-Committee of the Italian Association of Pediatric Hematology and Oncology (AIEOP)
Sep 9, 2015·Pediatric Transplantation·Volkan HazarTurkish Pediatric Bone Marrow Transplantation Study Group (TPBMT-SG)
Oct 18, 2012·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Mitchell S CairoJohn Pagel
Mar 7, 2020·British Journal of Haematology·Maria L MoletiRobin Foà
Aug 7, 2020·Journal of the National Comprehensive Cancer Network : JNCCN·Aliza Gardenswartz, Mitchell S Cairo
Nov 12, 2017·Paediatric Drugs·Christine Mauz-KörholzDieter Körholz

Related Concepts

IAPVP-16 Protocol
Antineoplastic Chemotherapy Protocols
BiCNU
Cyclophosphamide, (S)-Isomer
Riboposid
Hodgkin Lymphoma, Lymphocyte Depletion
Lung Diseases
Reticulosarcoma
Relapse
Remission Induction

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