Autologous platelet gel in total knee arthroplasty: a prospective randomized study.

Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA
Wieger G HorstmannPeter A M Everts

Abstract

Total knee arthroplasty (TKA) is often associated with major postoperative blood loss, postoperative pain, and impaired wound healing. The application of autologous platelet gel (APG), prepared from the buffy coat of a unit of autologous blood, has been advocated to improve haemostasis after surgery, to decrease perioperative blood loss, diminish postoperative pain and to enhance the wound healing process. This randomized controlled pilot study was developed to assess the effects of APG after total knee arthroplasty on blood loss, wound healing, pain, range of motion, and hospital stay. A prospective, randomized observer blind controlled trial was performed. Forty patients with only osteoarthritis of the knee were scheduled to have a TKA, and they were randomized into two groups. Patients in the treatment group were all treated with the application of autologous platelet gel after the prosthesis was implanted. Patients in the control group were treated with the same protocol but no APG was used. Preoperative and postoperative Hb levels showed no significant difference and allogenic blood transfusions were not given in either group. Haematomas were significantly larger in the control group than in the platelet gel group (P = 0.0...Continue Reading

Associated Clinical Trials

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Jul 7, 2012·JRSM Short Reports·Zafar AhmadNeil Rushton
Apr 25, 2014·Sports Medicine·Taralyn M McCarrelLisa A Fortier
Apr 11, 2014·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Alfredo Schiavone PanniChiara Del Regno
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Jan 6, 2021·Platelets·Peter A EvertsRonald D Gardner

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