Autologous skeletal-muscle-derived cell injection for anal incontinence due to obstetric trauma: a 5-year follow-up of an initial study of 10 patients

Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland
A FrudingerS Halligan

Abstract

Our aim was to determine whether the benefits of autologous skeletal-muscle-derived cell injection to treat obstetric anal incontinence are sustained at 5 years. An observational study was performed of 10 women suffering from obstetric anal incontinence refractory to non-surgical therapy. Autologous skeletal-muscle-derived cells were injected into the external sphincter defect under ultrasound guidance. Incontinence diaries and quality of life questionnaires were obtained pre-implantation and annually after implantation for 5 years. Anal physiology testing was performed before implantation and at 1, 2 and 5 years after implantation. The end-points included were adverse events, Wexner incontinence scores, incontinence episodes, anal squeeze pressures and quality of life over 5 years. An independent statistician used multilevel linear regression to analyse changes in repeated measures over time. Any skewed distributions were log transformed prior to analysis. No procedure-related adverse events occurred and haematological and biochemical parameters were normal during the 5-year period. There were sustained significant improvements in the Wexner incontinence score and reduced frequency of defaecation and number of incontinence epi...Continue Reading

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Citations

Jun 5, 2016·Gastroenterology Clinics of North America·Alison Freeman, Stacy Menees
Jun 18, 2016·International Urogynecology Journal·Søren GräsGunnar Lose
Dec 13, 2016·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·W W KhafagyM T El-Shobaky
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Nov 29, 2020·International Urogynecology Journal·Andre PlairGopal Badlani

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