Autologous skeletal myoblast transplantation for the treatment of postinfarction myocardial injury: phase I clinical study with 12 months of follow-up

American Heart Journal
Tomasz SiminiakMaciej Kurpisz

Abstract

Experimental studies have shown that skeletal myoblast transplantation into an area of postinfarction left ventricular injury results in an increase of segmental contractile performance that could be related to transplanted myoblasts. Initial experience with autologous skeletal myoblast transplantation in patients with postinfarction myocardial injury has also been obtained. Patients who survived an acute myocardial infarction and were scheduled to undergo coronary artery bypass grafting were screened by means of dobutamine stress echocardiography and included into the study when no contractility changes within akinetic/dyskinetic segments were observed. Ten patients who gave informed consent were enrolled, and autologous myoblasts (satellite cells) were isolated from the skeletal muscle biopsy. Myoblast injections into the akinetic/dyskinetic area were performed after constriction of the anastomoses during the coronary artery bypass grafting procedure. Myoblast transplantations were performed after 3 weeks of in vitro culture in all patients. One patient died of a recent infarction at day 7 postoperatively because of a recent infarction in a remote area of the left ventricle. The left ventricular ejection fraction increased fr...Continue Reading

References

Sep 1, 1989·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·N B SchillerI Schnittger
Jul 1, 1995·The Annals of Thoracic Surgery·R C ChiuR L Kao
Feb 1, 1996·Circulation Research·R K LiM K Mohabeer
Mar 23, 1999·The Annals of Thoracic Surgery·B Z AtkinsD A Taylor
Jan 5, 2000·The Annals of Thoracic Surgery·T SakaiT M Yau
Feb 24, 2001·Lancet·P MenaschéJ P Marolleau
Jun 1, 2001·The Annals of Thoracic Surgery·R M El OakleyM H Yacoub
Mar 22, 2002·The New England Journal of Medicine·Arthur J MossUNKNOWN Multicenter Automatic Defibrillator Implantation Trial II Investigators
Apr 8, 2003·Journal of the American College of Cardiology·Philippe MenaschéDenis Duboc

❮ Previous
Next ❯

Citations

Jul 17, 2008·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Sabine Hombach-KlonischMarek Los
Oct 21, 2005·Basic Research in Cardiology·H C OttD A Taylor
Aug 29, 2006·Heart Failure Reviews·E LeontiadisD V Cokkinos
Apr 2, 2008·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Demosthenes Katritsis
Mar 28, 2007·Current Heart Failure Reports·Doris A Taylor, Andrey G Zenovich
Nov 3, 2006·Current Treatment Options in Cardiovascular Medicine·Hüseyin InceChristoph A Nienaber
Sep 1, 2008·Journal of Cardiovascular Translational Research·Philippe Menasché
Jul 13, 2011·Journal of Cardiovascular Translational Research·Sara S NunesMilica Radisic
Jun 1, 2012·Journal of Cardiovascular Translational Research·Niall G Campbell, Ken Suzuki
Apr 25, 2007·American Heart Journal·E Marc JolicoeurUNKNOWN National Heart, Lung, and Blood Institute Cell Therapy Working Group Members
Aug 22, 2006·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Gwendolen Y ChangJoseph C Wu
Mar 12, 2009·Molecular Therapy : the Journal of the American Society of Gene Therapy·Philippe Menasche
Feb 28, 2006·Nature Clinical Practice. Cardiovascular Medicine·Tomasz SiminiakMaciej Kurpisz
Feb 28, 2006·Nature Clinical Practice. Cardiovascular Medicine·Philippe MenaschéAlbert A Hagège
Feb 28, 2006·Nature Clinical Practice. Cardiovascular Medicine·Paul SteendijkPatrick W Serruys
Feb 28, 2006·Nature Clinical Practice. Cardiovascular Medicine·Emerson C Perin, Javier López
Feb 28, 2006·Nature Clinical Practice. Cardiovascular Medicine·Pedro L SánchezFrancisco Fernández-Avilés
Jan 19, 2007·Nature Clinical Practice. Cardiovascular Medicine·Marc S Penn
Feb 11, 2009·Antioxidants & Redox Signaling·Mohammad N Jameel, Jianyi Zhang
May 7, 2009·Antioxidants & Redox Signaling·Ebo D de Muinck
Aug 11, 2010·Antioxidants & Redox Signaling·Khawaja Husnain HaiderMuhammad Ashraf
Sep 6, 2007·Stem Cells and Development·Rishi Sharma, Ram Raghubir
Mar 7, 2009·Stem Cells and Development·Elske J SchabortCarola U Niesler
Jan 16, 2010·Tissue Engineering. Part C, Methods·Lee-Lee OngGustav Steinhoff
Mar 5, 2010·British Medical Bulletin·Joon Lee, Cesare M Terracciano
Jun 10, 2011·British Medical Bulletin·Konstantinos Malliaras, Eduardo Marbán
Aug 3, 2010·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Javier MorenoJulián Pérez-Villacastín
Nov 14, 2008·Transplantation·Nikolaos BonarosAlfred Kocher
Apr 28, 2005·Artificial Organs·Dorota FiszerTomasz Siminiak
Apr 29, 2006·Artificial Organs·A Ruchan AkarUmit Ozyurda
Feb 8, 2006·Annual Review of Physiology·Michael Rubart, Loren J Field
May 29, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Vasileios KarantalisJoshua M Hare
Jan 1, 2012·Journal of Blood Transfusion·Ralph S Mosca
Apr 27, 2007·American Journal of Nephrology·Shunsuke Ohnishi, Noritoshi Nagaya
Dec 28, 2007·Cells, Tissues, Organs·Michael Rubart, Loren J Field
Dec 17, 2009·Circulation·Huei-Sheng Vincent ChenMark Mercola
Apr 8, 2009·Circulation·Ester Macia, Penelope A Boyden
Apr 26, 2006·Circulation Journal : Official Journal of the Japanese Circulation Society·Yanmei WangXiaodong Zhang
Mar 1, 2005·Future Cardiology·Keiichi Fukuda
Oct 3, 2012·International Journal of Nanomedicine·Sheng LianMeidong Lang
Jul 1, 2008·Future Cardiology·Chao-Hung WangSubodh Verma
Dec 23, 2010·Future Cardiology·Robert J Henning
Jan 31, 2012·Imaging in Medicine·Yingli FuDara L Kraitchman
Dec 19, 2009·Regenerative Medicine·Priya R Baraniak, Todd C McDevitt
Nov 19, 2010·Regenerative Medicine·Shazia DurraniKhawaja Husnain Haider

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Regeneration

Cardiac regeneration enables the repair of irreversibly damaged heart tissue using cutting-edge science, including stem cell and cell-free therapy. Discover the latest research on cardiac regeneration here.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Antiarrhythmic Agents: Mechanisms of Action

Understanding the mechanism of action of antiarrhythmic agents is essential in developing new medications as treatment of cardiac arrhythmias is currently limited by the reduced availability of safe and effective drugs. Discover the latest research on Antiarrhythmic Agents: Mechanism of Action here.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.