Autologous small-caliber "biotube" vascular grafts with argatroban loading: a histomorphological examination after implantation to rabbits

Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Taiji WatanabeYasuhide Nakayama

Abstract

Functional autologous tubular tissues, termed "biotubes," have been developed as small-caliber vascular grafts. Biotubes can be easily and safely constructed in vivo by using a novel concept in regenerative medicine-in body tissue architecture technology, which requires neither clean specialized laboratories nor complex cell management. Biotubes with "anastomotic reinforcement cuffs" were prepared by embedding a silicone rod (diameter, 3 mm; length, 30 mm) as a mold in the dorsal subcutaneous pouches of rabbits. The rod was covered at both ends with 2 pieces of polyurethane sponge tubes (length, 3 mm), and it was removed when the grafts were harvested. These biotubes had homogeneous thin connective tissue walls (thickness: 76 +/- 37 microm) that were primarily composed of collagen and fibroblasts. The resulting cuff-impregnated biotubes were auto-implanted in the carotid arteries for predetermined periods of up to 12 weeks and then morphologically examined. On implantation of the biotubes after argatroban loading, the total patency was 9/11 without any instance of aneurysm formation or rupture. At 12 weeks after implantation, no significant neointimal thickening was observed (170 +/- 30 microm). In addition, minimal thrombus fo...Continue Reading

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Citations

Mar 10, 2010·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Masashi YamanamiYasuhide Nakayama
May 18, 2010·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Tomonori OieYasuhide Nakayama
Oct 1, 2010·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Tomonori OieYasuhide Nakayama
Aug 23, 2011·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Takeshi MoriwakiYasuhide Nakayama
Nov 30, 2012·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Masashi YamanamiYasuhide Nakayama
Dec 21, 2012·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Yoshiaki TakewaYasuhide Nakayama
Oct 15, 2011·Cells, Tissues, Organs·Marissa PeckNicolas L'Heureux
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Sep 29, 2011·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Yasuhide NakayamaHitoshi Yaku
May 13, 2011·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Taiji WatanabeYasuhide Nakayama
Aug 1, 2015·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Yasuhide NakayamaNoriko Okumura
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Jul 2, 2015·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Ryosuke IwaiYasuhide Nakayama
Mar 24, 2016·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Daizo IshiiYasuhide Nakayama
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Jun 30, 2011·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Yasuhide NakayamaHitoshi Yaku
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