Autologous spermatogonial stem cell transplantation in man: current obstacles for a future clinical application

Human Reproduction Update
Mieke GeensHerman Tournaye

Abstract

Fertility preservation is becoming an important issue in the management of the quality of life of prepubertal boys undergoing cancer treatment. At present, the only theoretical option for preservation of fertility in these boys is the preservation of the spermatogonial stem cells for autologous intratesticular stem cell transplantation. In animal models, this technique has shown promising results. However, before translation to the clinic, some major concerns should be evaluated. Improving the efficiency of the technique is one of the first goals for further research, besides evaluation of the safety of the clinical application. Also, the cryopreservation of the spermatogonial stem cells needs extra attention, since this first step will be crucial in the success of any clinical application. Another concern is the risk of malignant contamination of the testicular tissue in childhood cancer patients. Extensive research in this field and especially on the feasibility of decontaminating the testicular tissue will be inevitable. Another important, though overlooked, issue is the prevention of damage to the testicular niche cells. Finally, xenografting and in vitro proliferation/maturation of the spermatogonia should be studied as al...Continue Reading

References

Nov 22, 1994·Proceedings of the National Academy of Sciences of the United States of America·R L Brinster, M R Avarbock
Jun 1, 1996·Nature Medicine·M R AvarbockR L Brinster
Jul 1, 1996·Human Reproduction·H NewtonR Gosden
Oct 27, 1998·Tissue & Cell·M NaganoR L Brinster
Oct 31, 1998·Current Opinion in Immunology·C PatienceR A Weiss
Jun 22, 1999·Human Reproduction·G Bahadur, D Ralph
Jun 22, 1999·Human Reproduction·S SchlattE Nieschlag
Oct 21, 1999·Biology of Reproduction·I DobrinskiR L Brinster
Oct 25, 2000·Hospital Medicine·A B Waring, W H Wallace
Jul 31, 2001·Human Reproduction Update·S J Howell, S M Shalet
Jul 31, 2001·Human Reproduction Update·O Hovatta
Oct 19, 2001·Proceedings of the National Academy of Sciences of the United States of America·M NaganoR L Brinster
Jan 5, 2002·Human Reproduction·S SchlattE Nieschlag
Aug 16, 2002·Nature·Ali HonaramoozStefan Schlatt
Oct 23, 2002·Proceedings of the National Academy of Sciences of the United States of America·F Kent HamraDavid L Garbers
Feb 28, 2003·Biology of Reproduction·Makoto NaganoRalph L Brinster
Feb 28, 2003·Biology of Reproduction·Stefan SchlattIna Dobrinski
Apr 16, 2003·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Y Aubard
Apr 18, 2003·Biology of Reproduction·Mito Kanatsu-ShinoharaTakashi Shinohara
May 27, 2003·Archives of Disease in Childhood·W H B Wallace, A B Thomson
Jan 23, 2004·Biology of Reproduction·Ali HonaramoozIna Dobrinski
Mar 26, 2004·European Journal of Obstetrics, Gynecology, and Reproductive Biology·G M ColpiG Piediferro
Mar 26, 2004·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Debra A GookJ McBain
Aug 21, 2004·Human Reproduction Update·Herman TournayeAndré Van Steirteghem
Oct 13, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S D Fosså, H Magelssen
Oct 19, 2004·Human Reproduction·G Bahadur
Dec 17, 2004·Biology of Reproduction·Mito Kanatsu-ShinoharaTakashi Shinohara
Mar 24, 2005·Journal of the National Cancer Institute. Monographs·Leslie R Schover
Mar 24, 2005·Journal of the National Cancer Institute. Monographs·Sophie D FossåRolv Skjaerven
Jun 21, 2005·The Journal of Clinical Investigation·Kazutoshi FujitaAkihiko Okuyama

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Citations

Nov 8, 2008·Nature Medicine·Martin M Matzuk, Dolores J Lamb
Mar 2, 2010·Reproduction, Fertility, and Development·Yanfei Yang, Ali Honaramooz
Jan 6, 2010·Human Reproduction Update·Christine WynsJacques Donnez
Aug 17, 2011·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Einar StensvoldIrma C Oskam
Sep 4, 2013·Regenerative Medicine·Allan A Pacey, Harry D Moore
Apr 27, 2012·TheScientificWorldJournal·Slobodan VlajkovićVladisav Stefanović
Jan 29, 2011·Reproductive Biomedicine Online·K DiedrichUNKNOWN Evian Annual Reproduction (EVAR) Workshop Group 2009
Oct 7, 2015·Cellular and Molecular Life Sciences : CMLS·Shigeo SaitoKazunari K Yokoyama
Dec 8, 2009·Reproduction in Domestic Animals = Zuchthygiene·G KaulT A Rafeeqi
Mar 6, 2010·International Journal of Urology : Official Journal of the Japanese Urological Association·Gert R Dohle
Dec 3, 2014·Fertility and Sterility·Roberto Benavides-GarciaBrian P Hermann
Sep 1, 2016·International Journal of Experimental Pathology·Sandi Regina VasiliaushaEstela Sasso-Cerri
Jul 20, 2014·Stem Cells Translational Medicine·James F SmithNam D Tran
Jul 3, 2013·Cellular Reprogramming·Maryam BaazmCordian Beyer
Oct 6, 2012·The Journal of Clinical Endocrinology and Metabolism·Kirsi Jahnukainen, Jan-Bernd Stukenborg
Jul 13, 2017·In Vitro Cellular & Developmental Biology. Animal·Maryam BaazmAdib Zendedel
Mar 17, 2011·Reproductive Medicine and Biology·Kohei Yamaguchi, Masato Fujisawa

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