PMID: 15230293Jul 3, 2004Paper

Autologous stem cell transplantation for systemic lupus erythematosus

Lupus
D R W Jayne, A Tyndall

Abstract

Some patients with severe systemic lupus erythematosus do not respond to conventional immunosuppression or suffer severe side effects from such treatment. In order to explore the concept of immunoablation followed by haematopoietic stem cell transplantation (HSCT) or 'rescue', an international collaboration has occurred over the past seven years. The European Group for Blood and Marrow Transplantation (EBMT) and The European League Against Rheumatism (EULAR) have analysed their collective phase I and II studies and found a remission rate (based on a reduction of the SLEDAI to < 3) in 66%, one-third of whom later relapsed to some degree. The most often used protocol was cyclophosphamide (CY) and G-CSF for mobilization and CY plus anti thymocyte globulin as conditioning. Procedure related mortality was 12% in this sick group of patients with major organ involvement. The North American, mostly single centre experience showed higher rates of remission and one procedure related death. Some relapse was also observed. Phase II studies designed to assess the role of post-HSCT maintenance therapy are being considered by the EBMT/EULAR group.

References

Jul 9, 1999·QJM : Monthly Journal of the Association of Physicians·L BonoJ A Hicks
Mar 4, 2000·Annals of the Rheumatic Diseases·E TrysbergA Tarkowski
May 4, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S M KorbetR D Rohde
Mar 20, 2001·Lancet·O RosenR Arnold
Aug 11, 2001·Bone Marrow Transplantation·R K BurtP A McSweeney
Jan 16, 2002·Lupus·A M Marmont
Jan 16, 2003·Arthritis and Rheumatism·Michelle PetriRobert A Brodsky
Feb 25, 2003·Cancer Control : Journal of the Moffitt Cancer Center·Jacob M Van Laar, Alan Tyndall
May 4, 2004·Lupus·David JayneUNKNOWN European League Against Rheumatism Registry

❮ Previous
Next ❯

Citations

Nov 5, 2005·Acta Haematologica·Alan Tyndall, Thomas Daikeler
Sep 16, 2006·Nature Reviews. Immunology·Andreas RadbruchFalk Hiepe
Dec 16, 2016·American Journal of Physiology. Renal Physiology·Jianyong ZhongAgnes B Fogo
May 20, 2018·Journal of Neurodevelopmental Disorders·Erik Allen LykkenSteven James Gray
Jul 1, 2020·Scandinavian Journal of Immunology·Aicha LaghmouchiInge Jedema
Jun 8, 2004·British Journal of Haematology·J R PasswegUNKNOWN Autoimmune Disease Working Party of the EBMT
Apr 6, 2005·Clinical and Experimental Immunology·F Goldblatt, D A Isenberg
Jun 29, 2010·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Andreas Grützkau, Andreas Radbruch
May 1, 2005·Expert Review of Clinical Immunology·Alan Tyndall, Dominique Farge
Oct 4, 2007·Annals of the New York Academy of Sciences·F GualandiA Marmont
Dec 8, 2011·Journal of the American Academy of Nurse Practitioners·Marcia RobinsonLeanne M Currie
Mar 1, 2005·Lupus·H Tahir, D A Isenberg
Aug 26, 2014·Clinical Reviews in Allergy & Immunology·Bin LiuPatrick S C Leung
Jul 1, 2005·Expert Review of Clinical Immunology·Gisele Zandman-GoddardYehuda Shoenfeld
Nov 19, 2010·Expert Review of Hematology·Claudio AnnaloroGiorgio Lambertenghi Deliliers
Sep 8, 2012·Current Allergy and Asthma Reports·Sheryl MascarenhasStacy P Ardoin
Mar 25, 2021·Current Allergy and Asthma Reports·Sendhilnathan Ramalingam, Ankoor Shah

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Related Papers

The Journal of Rheumatology. Supplement
A Tyndall, EBMT/EULAR International Data Base. European Group for Blood and Marow Transplantation and European League Against Rheumatis
Lupus
D R W JayneEuropean League Against Rheumatism Registry
Best Practice & Research. Clinical Haematology
A GratwohlInternational Stem Cell Project for Autoimmune Diseases
© 2022 Meta ULC. All rights reserved