Abstract
High-dose chemotherapy and autologous stem cell transplantation (ASCT) can offer durable remission in many patients with relapsed or high-risk lymphoma. However, elderly patients are often not considered ASCT candidates based on age alone. A retrospective analysis of patients ≥70 years of age with a diagnosis of Hodgkin or non-Hodgkin lymphoma receiving ASCT between 2000 and 2016 at two partner institutions was performed. Clinical data were extracted from institutional databases and individual medical records. Multivariate analysis was performed to examine the association of clinical variables with transplant outcomes. One hundred seven patients were identified. Median age at transplant was 72 years (range, 70-79). The most common lymphoma subtype was diffuse large B-cell (n = 63, 59%). Median time to neutrophil and platelet engraftment were 10 and 12 days, respectively. With a median follow-up for survivors of 20 months following ASCT (range, 6 months to 13.1 years), estimates for 2-year progression-free survival and overall survival were 58% (95% confidence interval [CI], 48%-67%) and 65% (95% CI, 55%-74%), respectively. Two-year estimate for relapse was 34% (95% CI, 25%-44%) and nonrelapse mortality (NRM) was 7% (95% CI, 3%-...Continue Reading
References
Dec 7, 1995·The New England Journal of Medicine·T PhilipJ L Harousseau
Jan 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C R Kusnierz-GlazG D Long
Mar 9, 2000·Annals of Oncology : Official Journal of the European Society for Medical Oncology·H C SchoutenP M Fayers
Oct 24, 2000·Bone Marrow Transplantation·E JantunenT Nousiainen
Apr 25, 2001·Bone Marrow Transplantation·A K GopalO W Press
Jun 28, 2002·Lancet·Norbert SchmitzUNKNOWN Lymphoma Working Party of the European Group for Blood and Marrow Transplantation
Jul 5, 2005·Blood·Mohamed L SorrorBarry Storer
Oct 21, 2005·Leukemia & Lymphoma·L R MileshkinH M Prince
Jan 18, 2006·Bone Marrow Transplantation·E JantunenT Nousiainen
Apr 25, 2006·Bone Marrow Transplantation·F K BuadiD J Inwards
Feb 15, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C HosingI Khouri
Jun 11, 2008·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Tanya M WildesSteven M Devine
Jul 16, 2008·Blood·Christian H GeislerUNKNOWN Nordic Lymphoma Group
Sep 17, 2008·Bone Marrow Transplantation·R Z YusufK K Ballen
Oct 8, 2008·Haematologica·Esa JantunenUNKNOWN EBMT Lymphoma Working Party
Jul 28, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christian GisselbrechtNorbert Schmitz
Dec 15, 2010·Bone Marrow Transplantation·D J AndorskyL Pinter-Brown
Apr 7, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E JantunenA Sureda
Mar 1, 2012·American Journal of Hematology·Rebecca L ElstromUsama Gergis
Aug 2, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Francesco d'AmoreHelle E Toldbod
Feb 5, 2014·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Dai ChiharaJunji Suzumiya
Sep 2, 2014·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Parastoo B DahiCraig S Sauter
Jun 28, 2015·Journal of Geriatric Oncology·E HermetUNKNOWN Société Française de Greffe de Moelle et de Thérapie Cellulaire
Jun 30, 2015·British Journal of Haematology·Satyen H GohilKarl S Peggs
Oct 28, 2016·British Journal of Haematology·Christian W EskelundChristian H Geisler
Dec 4, 2016·Hematology·Andrew S Artz
Jan 10, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christopher J GibsonBenjamin L Ebert
Apr 4, 2017·Cancer·Zachariah DeFilippYi-Bin Chen
Apr 25, 2017·Bone Marrow Transplantation·E SchorbB Kasenda
Jan 1, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E JantunenA Sureda
Citations
May 29, 2018·British Journal of Haematology·Christian Gisselbrecht, Eric Van Den Neste
Oct 12, 2018·Drugs & Aging·Zeina Al-MansourJan Cerny
Jul 4, 2019·Expert Review of Hematology·Catherine Tang, John Kuruvilla
Jun 7, 2019·Current Opinion in Hematology·Michael ScordoCraig S Sauter
Mar 18, 2020·Blood·Sattva S NeelapuFrederick L Locke
Sep 5, 2020·Bone Marrow Transplantation·Robert PytlíkMarek Trněný
Aug 4, 2020·Expert Review of Hematology·Elisa SantambrogioUmberto Vitolo
Jan 7, 2021·Annals of Hematology·Hiroki HosoiTakashi Sonoki
Oct 17, 2020·Clinical Lymphoma, Myeloma & Leukemia·Panayotis KaloyannidisHani Al Hashmi
Apr 1, 2021·Nature Reviews. Nephrology·Frank BridouxNelson Leung
Jun 22, 2021·Blood Advances·Parastoo B DahiSergio A Giralt