journal cover

Autologous stem cell transplantation in autoimmune and rheumatic diseases: from the molecular background to clinical applications

Scandinavian Journal of Rheumatology

Feb 6, 2010

Peter SzodorayMargit Zeher

Download from

Publisher
PubMed

Abstract

Autoimmune diseases have a multifactorial origin. Because of disturbances of the immune system, autoreactive T and B cells target self-antigens, leading to permanent organ damage. Despite novel therapeutic protocols, the disease course is chronic and in many instances the outcome is let...read more

Mentioned in this Paper

Immune System
Microdosing Trials, Human
Graft Survival
Evaluation Studies, FDA Phase II as Topic
Rheumatoid Arthritis
Graft Rejection
Autoimmune Diseases
Juvenile-Onset Still Disease
Chromosome Aberrations
CD34 Antigens
Paper Details
References
  • References52
  • Citations8
12345...
  • References52
  • Citations8
1

Feeds With Similar Papers

Juvenile Arthritis

Juvenile arthritis is any form of chronic arthritis or chronic arthritis-related conditions which affects individuals under the age of 16. Discover the latest research juvenile arthritis.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Chromosomal Abnormalities

Chromosome abnormalities can be classified as either structural or numerical. Numerical abnormalities include duplications or deletion of a pair of chromosomes, such as Down Syndrome. Structural abnormalities include missing, extra or switched parts of a chromosome. Discover the latest research on chromosomal abnormalities here.

Human Immune Variation: Genetics, Gender & Time

Establishing the normal range of phenotypic variation within and between individuals requires consideration of contributions from genetics and the environment. Find the latest research on variations in the human immune system here.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

HSC Transplantation

Hematopoietic stem cell (HCT) transplants have been used as treatment options for some types of cancer including lymphoma and leukemia as well as some immunodeficiency illnesses and congenital abnormalities. Currently research is underway into the potential use of HCTs in genetic disorders. Here is the latest research on HCT transplantation.

Immune System in Humans: Tissues & Ages

Mapping the human immune system spatially, within and between tissues, will provide the basis for studying mechanisms of tissue residency and the effects of aging. Find new research on analysis of the immune system by multiple approaches here.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Hematopoetic Stem Cells

Hematopoietic stem cells (HSCs) are the cells that give rise to blood cells of the myeloid and lymphoid lineage during hematopoiesis. HSC transplantation is an established therapeutic option for both malignant and nonmalignant indications. Here is the latest research.

Graft Rejection

Graft rejection occurs when the donor's grafted tissue is rejected by the recipient's immune system, destroying the transplanted tissue. Discover the latest research on graft rejection here.

Human Immune Variation: Genetic, Gender & Time

Establishing the normal range of phenotypic variation within and between individuals requires consideration of contributions from genetics and the environment. Find the latest research on variations in the human immune system here.

Immune Tolerance

Immune tolerance happens when the immune system is not responsive to a substance or organism and does not elicit an immune response. This is a normal physiological response for some antigens, especially when detecting self from non-self. This has been a potential area of therapy for some disorders. Here is the latest research on immune tolerance.

Systemic Juvenile Idiopathic Arthritis

Systemic juvenile idiopathic arthritis is a rare rheumatic disease that affects children. Symptoms include joint pain, but also fevers and skin rashes. Here is the latest on this disease.

Systemic Autoimmunity

Systemic autoimmunity is a complex disease process that results from a loss of immunological tolerance, characterized by the inability of the immune system to discriminate self from non-self. Discover the latest research on Systemic Autoimmunity here.

© 2020 Meta ULC. All rights reserved

Autologous stem cell transplantation in autoimmune and rheumatic diseases: from the molecular background to clinical applications

Scandinavian Journal of Rheumatology

Feb 6, 2010

Peter SzodorayMargit Zeher

PMID: 20132064

DOI: 10.3109/03009740903030324

Abstract

Autoimmune diseases have a multifactorial origin. Because of disturbances of the immune system, autoreactive T and B cells target self-antigens, leading to permanent organ damage. Despite novel therapeutic protocols, the disease course is chronic and in many instances the outcome is let...read more

Mentioned in this Paper

Immune System
Microdosing Trials, Human
Graft Survival
Evaluation Studies, FDA Phase II as Topic
Rheumatoid Arthritis
Graft Rejection
Autoimmune Diseases
Juvenile-Onset Still Disease
Chromosome Aberrations
CD34 Antigens

Feeds With Similar Papers

Juvenile Arthritis

Juvenile arthritis is any form of chronic arthritis or chronic arthritis-related conditions which affects individuals under the age of 16. Discover the latest research juvenile arthritis.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

Paper Details
References
  • References52
  • Citations8
12345...
  • References52
  • Citations8
1

Download from

Publisher
PubMed
/papers/autologous-stem-cell-transplantation-in/20132064