Autologous suction blister grafting for chronic leg ulcers

Journal of the European Academy of Dermatology and Venereology : JEADV
U CostanzoL R Braathen

Abstract

Non-healing leg ulcers represent a treatment problem. Investigate grafting of autologous suction blister roofs as treatment. Twenty-nine chronic, non-healing leg ulcers of various aetiologies in 18 inpatients were treated by autologous epidermal grafting using the roofs of suction blisters. 55% of ulcers completely healed 2 to 6 weeks after grafting. A 50-90% reduction in size was documented in 34% and no change was observed in 11% of ulcers. Twelve weeks after grafting, 89% of ulcers were healed completely. In most ulcers, we observed a stimulation of reepithelialization from the wound edge ('edge effect') and an accelerated formation of healthy granulation tissue. During a follow-up period of 12 months, 90% of the ulcers remained healed. Grafting of autologous suction blister roofs is an effective treatment option for non-healing leg ulcers. The advantages of the method are its lack of pain, low costs and immediate availability.

References

Feb 1, 1991·Journal of Cutaneous Pathology·E M WillsteedP H Mckee
Nov 1, 1987·The British Journal of Dermatology·I M LeighT J Phillips
Nov 1, 1986·Clinical and Experimental Dermatology·I M Leigh, P E Purkis
Mar 1, 1986·Journal of the American Academy of Dermatology·J M HeftonD M Carter
Feb 1, 1968·The Journal of Investigative Dermatology·U Kiistala
Sep 1, 1993·Clinical and Experimental Dermatology·I R HarrisW J Cunliffe
Aug 24, 1999·Archives of Dermatology·F A Bahmer

❮ Previous
Next ❯

Citations

Aug 10, 2018·International Wound Journal·Blandine Vinceneux TalvandeHervé Maillard
Sep 30, 2009·The British Journal of Surgery·M J Sultan, C McCollum
Mar 2, 2019·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Flavia Angeletti, Roland Kaufmann
Apr 9, 2019·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Flavia Angeletti, Roland Kaufmann
Jul 16, 2013·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Silvan KleinLukas Prantl

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

© 2021 Meta ULC. All rights reserved