Autologous transplantation of adipose-derived mesenchymal stem cells ameliorates streptozotocin-induced diabetic nephropathy in rats by inhibiting oxidative stress, pro-inflammatory cytokines and the p38 MAPK signaling pathway

International Journal of Molecular Medicine
Yan FangDehua Li

Abstract

Diabetic nephropathy is the leading cause of end-stage renal disease. The aim of this study was to investigate the renoprotective effects of autologous transplantation of adipose-derived mesenchymal stem cells (ADMSCs) and to delineate its underlying mechanisms of action in diabetic nephropathy. Diabetes was induced in adult male Sprague-Dawley rats by streptozotocin (STZ) injection. ADMSCs were administered intravenously 4 weeks after STZ injection and metabolic indices and renal structure were assessed (12 weeks). Markers of diabetes including blood glucose, cholesterol, triglycerides, urea nitrogen and creatinine were measured. Renal pathology, levels of oxidative stress and the expression of pro-inflammatory cytokines and the MAPK signaling pathway members were also determined. Autologous transplantation of ADMSCs significantly attenuated common metabolic disorder symptoms associated with diabetes. Furthermore, ADMSC administration minimized pathological alterations, reduced oxidative damage and suppressed the expression of pro-inflammatory cytokines in the renal tissues of diabetic rats. ADMSC transplantation also decreased the expression of p-p38, p-ERK and p-JNK, which are all important molecules of the MAPK signaling pa...Continue Reading

Citations

Jan 28, 2014·Current Diabetes Reports·Aaron Liew, Timothy O'Brien
Mar 1, 2016·Kidney International·LaTonya J HicksonLilach O Lerman
Jun 15, 2013·Stem Cells·Xiang-Yang ZhuLilach O Lerman
Jul 9, 2014·BioMed Research International·Meiling JinXiangmei Chen
Jun 18, 2014·Frontiers in Endocrinology·Grace C DaveyTimothy O'Brien
Dec 16, 2016·American Journal of Physiology. Renal Physiology·Jianyong ZhongAgnes B Fogo
Jun 2, 2017·American Journal of Physiology. Renal Physiology·Salma MalikDharamvir Singh Arya
Jul 20, 2019·Journal of Immunology Research·Meng SunZhenxu Zhou
Jan 13, 2018·International Journal of Molecular Medicine·Marina DevetziVassilis Zoumpourlis
Apr 23, 2015·Journal of the American Society of Nephrology : JASN·Federica CollinoGiovanni Camussi
May 27, 2020·Journal of Cellular Physiology·Shirin TavakoliAdel Naimi
Sep 16, 2017·BioMed Research International·Umar BachaAftab Ahmad Anjum
Jul 30, 2019·Oxidative Medicine and Cellular Longevity·Chang-Chun HsiaoChien-Te Lee
Jan 7, 2017·Stem Cells International·Janaina PauliniÉrika B Rangel

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.