[Autologous transplantation of cultivated limbal epithelium].

Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
D MellerK-P Steuhl

Abstract

In this study the clinical outcome of ex vivo expansion of autologous limbal epithelial cells on intact amniotic membranes (AM) for ocular surface reconstruction in limbal stem cell deficiency (LSCD) was investigated. A total of 30 eyes in 28 patients (22 male and 6 female) with total (n=18) or partial (n=12) LSCD were treated by transplantation of autologous limbal epithelial cells after expansion on intact AM. The causes of LSCD in the patients were chemical and thermal burns (n=16), pterygium (n=9), tumor excision (n=2), perforating injury, mitomycin C-induced LSCD and epidermolysis bullosa (each n=1). Only eyes with a follow-up time of at least 9 months were included in the analysis. The main outcome criteria were restoration of ocular surface integrity and improvement of visual acuity (VA). The mean follow-up time was 28.9±15.5 months. An entirely stable corneal surface was reconstructed in 23 (76.7%) eyes. Visual acuity increased significantly in 21 (70%) eyes, was stable in 8 (26.7%) eyes and decreased in 1 (3.3%) eye. The mean visual acuity increased significantly (p<0.0001) from a preoperative value of 1.58±0.97 LogMAR to 0.6±0.49 LogMAR. Transplantation of limbal epithelium cultivated on intact AM restores a stable co...Continue Reading

References

Oct 1, 1995·Ophthalmology·V Puangsricharern, S C Tseng
Jul 13, 2000·The New England Journal of Medicine·R J TsaiJ K Chen
Oct 12, 2001·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·D Meller, F Kruse
Mar 27, 2002·The British Journal of Ophthalmology·D MellerS C G Tseng
Jun 26, 2003·Investigative Ophthalmology & Visual Science·Elias E Hernandez GalindoDaniel Meller
Apr 27, 2004·Experimental Eye Research·Robert M LavkerTung-Tien Sun
Jan 16, 2007·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Thomas FuchslugerDaniel Meller
Jan 24, 2009·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·M PauklinD Meller

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Citations

Nov 1, 2011·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·H G Struck, N F Schrage
Sep 13, 2011·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·P Eberwein, T Reinhard
Aug 31, 2012·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·K-P Steuhl
Aug 31, 2012·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·D MellerK-P Steuhl
Jun 14, 2013·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·D MellerK-P Steuhl
Nov 16, 2011·Tissue Engineering. Part C, Methods·Maryam A ShafiqAli R Djalilian
Oct 1, 2011·Current Eye Research·Mikk PauklinDaniel Meller
Feb 28, 2017·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·D Meller, H Thomasen

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