Autologous transplantation of mesenchymal stromal cells tends to prevent progress of interstitial fibrosis in a rhesus Macaca mulatta monkey model of chronic kidney disease

Cytotherapy
Reza MoghadasaliNasser Aghdami

Abstract

Chronic kidney disease (CKD) attributed to cisplatin is well documented. Mesenchymal stromal cells (MSCs) are proven to be renotropic. Although they have been shown to improve function in CKD and reduce fibrosis in different experimental rodent models, their efficiency in primates is unknown. The present study aimed to evaluate the prevention of CKD and reduction of fibrosis in monkeys treated with MSCs after cisplatin nephrotoxicity. We induced CKD in adult rhesus Macaca mulatta monkeys by means of intravenous administration of cisplatin. Autologous MSCs were transplanted by means of intrarenal arterial injections to assess the adverse effects of cisplatin in two CKD models: preventative and stable. Preventative CKD monkeys (n = 3) underwent cell transplantation 4 days after the cisplatin injection. The stable CKD monkeys (n = 2) underwent cell transplantation 6 months after the cisplatin injection. Non-treated (n = 4) and normal saline-injected animals (n = 3) comprised the control and vehicle groups, respectively. We followed the animals for survival rate, serum biochemistry, urine analysis and histopathological indices. In the preventive CKD model, MSC transplantation tended to improve some renal functions but significantly...Continue Reading

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Citations

Jul 28, 2016·Nefrología : publicación oficial de la Sociedad Española Nefrologia·Jordi RoviraMaría José Ramírez-Bajo
Jan 16, 2019·Journal of Cellular Physiology·Talieh MalekshahabiReza Moghadasali
Sep 18, 2018·Clinical Science·Meg L McFetridgeSharon D Ricardo
Oct 12, 2018·Stem Cells Translational Medicine·Julia MarchequeLaura Perin
May 21, 2020·Frontiers in Cell and Developmental Biology·María José Ramírez-BajoFritz Diekmann
May 26, 2017·Stem Cell Research & Therapy·Atieh MakhloughNasser Aghdami
Nov 13, 2020·World Journal of Stem Cells·Perrine BurdeyronClara Steichen
Mar 18, 2021·The American Journal of the Medical Sciences·HaiYan ZhaoWenJi Wang

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