Abstract
Glycoprotein-96, a non-polymorphic heat-shock protein, associates with intracellular peptides. Autologous tumor-derived heat shock protein-peptide complex 96 (HSPPC-96) can elicit potent tumor-specific T cell responses and protective immunity in animal models. We sought to investigate the feasibility, safety, and antitumor activity of HSPPC-96 vaccines prepared from tumor specimens of patients with metastatic melanoma. Patients with a Karnofsky Performance Status >70% and stage III or stage IV melanoma had to have a metastasis >3 cm in diameter resectable as part of routine clinical management. HSPPC-96 tumor-derived vaccines were prepared in one of three dose levels (2.5, 25, or 100 microg/dose) and administered as an intradermal injection weekly for 4 consecutive weeks. In vivo induction of immunity was evaluated using delayed-type hypersensitivity (DTH) to HSPPC-96, irradiated tumor, and dinitrochlorobenzene (DNCB). The gamma-interferon (IFNgamma) ELISPOT assay was used to measure induction of a peripheral blood mononuclear cell response against autologous tumor cells at baseline and at the beginning of weeks 3, 4, and 8. Among 36 patients enrolled, 72% had stage IV melanoma and 83% had received prior systemic therapy. The s...Continue Reading
References
Mar 1, 1975·Cancer·F R EilberD L Morton
May 18, 1990·Science·R P BeckmannW J Welch
Jul 28, 1989·Science·G C FlynnJ E Rothman
Feb 24, 1972·The New England Journal of Medicine·W J CatalonaP B Chretien
Dec 16, 1983·Journal of Immunological Methods·C C CzerkinskyA Tarkowski
May 15, 1981·Cancer·E S CamachoH F Oettgen
Sep 15, 1995·Science·R Suto, P K Srivastava
Jul 14, 1994·Nature·J FrydmanF U Hartl
Jan 1, 1994·Immunogenetics·P K SrivastavaZ Li
Nov 1, 1993·Journal of Immunotherapy with Emphasis on Tumor Immunology : Official Journal of the Society for Biological Therapy·N E BlachereP K Srivastava
Oct 6, 1997·Science·Y TamuraP K Srivastava
Dec 16, 1997·Proceedings of the National Academy of Sciences of the United States of America·K SuzueR A Young
Jul 18, 2000·International Journal of Cancer. Journal International Du Cancer·J J LewisA N Houghton
Sep 27, 2000·International Journal of Cancer. Journal International Du Cancer·S JanetzkiP K Srivastava
Apr 6, 2001·Immunity·S BasuP K Srivastava
Jul 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·C A Piccirillo, E M Shevach
Nov 9, 2001·Annual Review of Genetics·S W FewellJ L Brodsky
Jun 28, 2002·Nature Immunology·Jackson G EgenJames P Allison
Aug 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rosângela Salerno-GoncalvesMarcelo B Sztein
Oct 16, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Filiberto BelliGiorgio Parmiani
Nov 20, 2002·Journal of Virology·Florence BuseyneYves Rivière
Dec 24, 2002·Current Opinion in Immunology·Julie C Baker-LePainChristopher V Nicchitta
Nov 20, 2003·Methods : a Companion to Methods in Enzymology·Neal F Gordon, Brian L Clark
Jun 6, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrew D Wells
Citations
Sep 21, 2000·Immunology Letters·K M Anderson, P K Srivastava
Apr 18, 2012·Oncogene·B Luo, A S Lee
Apr 13, 2012·Journal of Immunotherapy·Yanan Liu, Gang Zeng
Mar 29, 2014·Expert Opinion on Biological Therapy·Giulio TostiChiara Martinoli
Aug 2, 2011·Expert Opinion on Biological Therapy·Alessandra di PietroAlessandro Testori
Oct 29, 2010·Expert Opinion on Biological Therapy·Kewal K Jain
Jul 20, 2012·Cancer Letters·Brian M Andersen, John R Ohlfest
Nov 21, 2013·Immunologic Research·Natasa StrboEckhard R Podack
Nov 5, 2011·International Journal of Cancer. Journal International Du Cancer·Marco RandazzoChristian Kleist
Mar 1, 2011·Journal of Experimental & Clinical Cancer Research : CR·Quan-Yi GuoShi-Bi Lu
Aug 25, 2015·Frontiers in Immunology·Jitka FucikovaRadek Spisek
Aug 13, 2015·Chinese Medical Journal·Yu WangJiang Peng
May 12, 2015·PloS One·Yunfei ZhangWen Luo
Jan 22, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hansje-Eva TeulingsRosalie M Luiten
Mar 2, 2013·Technology in Cancer Research & Treatment·H-Z LiJ-W Chang
Feb 2, 2018·Vaccines·Alexandra CadenaMaria Angelica Cortez
Feb 10, 2018·Immunotherapy·Maureen L AliruSunil Krishnan
Feb 22, 2016·Journal of Neuro-oncology·Shamik ChakrabortyJohn A Boockvar
May 18, 2018·JCI Insight·Nan JiZhixian Gao
Mar 31, 2021·Neurosurgery Clinics of North America·Justin LeeLinda M Liau
Aug 11, 2021·Scientific Reports·Abigail L SedlacekRobert J Binder