Autologous tumor-derived heat-shock protein peptide complex-96 (HSPPC-96) in patients with metastatic melanoma.

Journal of Translational Medicine
Omar EtonJeffrey E Lee

Abstract

Glycoprotein-96, a non-polymorphic heat-shock protein, associates with intracellular peptides. Autologous tumor-derived heat shock protein-peptide complex 96 (HSPPC-96) can elicit potent tumor-specific T cell responses and protective immunity in animal models. We sought to investigate the feasibility, safety, and antitumor activity of HSPPC-96 vaccines prepared from tumor specimens of patients with metastatic melanoma. Patients with a Karnofsky Performance Status >70% and stage III or stage IV melanoma had to have a metastasis >3 cm in diameter resectable as part of routine clinical management. HSPPC-96 tumor-derived vaccines were prepared in one of three dose levels (2.5, 25, or 100 microg/dose) and administered as an intradermal injection weekly for 4 consecutive weeks. In vivo induction of immunity was evaluated using delayed-type hypersensitivity (DTH) to HSPPC-96, irradiated tumor, and dinitrochlorobenzene (DNCB). The gamma-interferon (IFNgamma) ELISPOT assay was used to measure induction of a peripheral blood mononuclear cell response against autologous tumor cells at baseline and at the beginning of weeks 3, 4, and 8. Among 36 patients enrolled, 72% had stage IV melanoma and 83% had received prior systemic therapy. The s...Continue Reading

References

Feb 24, 1972·The New England Journal of Medicine·W J CatalonaP B Chretien
Dec 16, 1983·Journal of Immunological Methods·C C CzerkinskyA Tarkowski
Nov 1, 1993·Journal of Immunotherapy with Emphasis on Tumor Immunology : Official Journal of the Society for Biological Therapy·N E BlachereP K Srivastava
Dec 16, 1997·Proceedings of the National Academy of Sciences of the United States of America·K SuzueR A Young
Sep 27, 2000·International Journal of Cancer. Journal International Du Cancer·S JanetzkiP K Srivastava
Jul 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·C A Piccirillo, E M Shevach
Nov 9, 2001·Annual Review of Genetics·S W FewellJ L Brodsky
Jun 28, 2002·Nature Immunology·Jackson G EgenJames P Allison
Aug 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rosângela Salerno-GoncalvesMarcelo B Sztein
Oct 16, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Filiberto BelliGiorgio Parmiani
Dec 24, 2002·Current Opinion in Immunology·Julie C Baker-LePainChristopher V Nicchitta
Nov 20, 2003·Methods : a Companion to Methods in Enzymology·Neal F Gordon, Brian L Clark
Jun 6, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrew D Wells

❮ Previous
Next ❯

Citations

Mar 29, 2014·Expert Opinion on Biological Therapy·Giulio TostiChiara Martinoli
Aug 2, 2011·Expert Opinion on Biological Therapy·Alessandra di PietroAlessandro Testori
Oct 29, 2010·Expert Opinion on Biological Therapy·Kewal K Jain
Jul 20, 2012·Cancer Letters·Brian M Andersen, John R Ohlfest
Nov 21, 2013·Immunologic Research·Natasa StrboEckhard R Podack
Nov 5, 2011·International Journal of Cancer. Journal International Du Cancer·Marco RandazzoChristian Kleist
Mar 1, 2011·Journal of Experimental & Clinical Cancer Research : CR·Quan-Yi GuoShi-Bi Lu
Aug 25, 2015·Frontiers in Immunology·Jitka FucikovaRadek Spisek
Aug 13, 2015·Chinese Medical Journal·Yu WangJiang Peng
Jan 22, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hansje-Eva TeulingsRosalie M Luiten
Mar 2, 2013·Technology in Cancer Research & Treatment·H-Z LiJ-W Chang
Feb 2, 2018·Vaccines·Alexandra CadenaMaria Angelica Cortez
Feb 10, 2018·Immunotherapy·Maureen L AliruSunil Krishnan
Feb 22, 2016·Journal of Neuro-oncology·Shamik ChakrabortyJohn A Boockvar
Mar 31, 2021·Neurosurgery Clinics of North America·Justin LeeLinda M Liau

❮ Previous
Next ❯

Methods Mentioned

BETA
ion-exchange chromatography
biopsy
dissecting
surgical resection
amputation

Related Concepts

Related Feeds

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.

Avian Influenza: Innate Immune Adjuvant

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Avian Influenza: Innate Immune Adjuvant (ASM)

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.