Automated and robust organ segmentation for 3D-based internal dose calculation.

EJNMMI Research
Mahmood NazariSharok Kimiaei

Abstract

In this work, we address image segmentation in the scope of dosimetry using deep learning and make three main contributions: (a) to extend and optimize the architecture of an existing convolutional neural network (CNN) in order to obtain a fast, robust and accurate computed tomography (CT)-based organ segmentation method for kidneys and livers; (b) to train the CNN with an inhomogeneous set of CT scans and validate the CNN for daily dosimetry; and (c) to evaluate dosimetry results obtained using automated organ segmentation in comparison with manual segmentation done by two independent experts. We adapted a performant deep learning approach using CT-images to delineate organ boundaries with sufficiently high accuracy and adequate processing time. The segmented organs were consequently used as binary masks for further convolution with a point spread function to retrieve the activity values from quantitatively reconstructed SPECT images for "volumetric"/3D dosimetry. The resulting activities were used to perform dosimetry calculations with the kidneys as source organs. The computational expense of the algorithm was sufficient for clinical daily routine, required minimum pre-processing and performed with acceptable accuracy a Dice...Continue Reading

References

Jan 1, 1996·Physics in Medicine and Biology·U SchneiderA Lomax
Jan 27, 2004·Journal of Chemical Information and Computer Sciences·Douglas M Hawkins
Feb 1, 2006·IEEE Transactions on Information Technology in Biomedicine : a Publication of the IEEE Engineering in Medicine and Biology Society·Daw-Tung LinSiu-Wan Hung
Dec 7, 2007·Medical Image Computing and Computer-assisted Intervention : MICCAI·Toshiyuki OkadaShinichi Tamura
Mar 5, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Wesley E BolchStephen R Thomas
Jun 30, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Yuni K DewarajaMichael Ljungberg
Jul 10, 2012·Magnetic Resonance Imaging·Andriy FedorovRon Kikinis
Oct 3, 2013·European Journal of Nuclear Medicine and Molecular Imaging·A RomerM A Walter
Feb 8, 2014·European Journal of Nuclear Medicine and Molecular Imaging·Samer EzziddinAmir Sabet
Oct 17, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Michael LjungbergStephan Walrand
Aug 20, 2016·IEEE Transactions on Pattern Analysis and Machine Intelligence· Shaoqing Ren Jian Sun
Jan 28, 2017·Scientific Reports·Michiru NishitaYasuhiro Minami
Jun 16, 2017·Insights Into Imaging·Akshat GotraAn Tang
Dec 16, 2017·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Min Sun LeeJae Sung Lee
Jul 12, 2018·IEEE Transactions on Medical Imaging·Xiaomeng LiPheng-Ann Heng
Feb 1, 2019·IEEE Transactions on Neural Networks and Learning Systems·Zhong-Qiu ZhaoXindong Wu
May 31, 2019·Journal of Digital Imaging·Mohammad Hesam HesamianPaul Kennedy

❮ Previous
Next ❯

Software Mentioned

Mask
Nvidia
QDOSE
rcnn
RoIPool
RoI
Align

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.