PMID: 12788198Jun 6, 2003Paper

Automated beam angle and weight selection in radiotherapy treatment planning applied to pancreas tumors

International Journal of Radiation Oncology, Biology, Physics
Evert Woudstra, Ben J M Heijmen

Abstract

To extend and investigate the clinical value of a recently developed algorithm for automatic beam angle and beam weight selection, for irradiation of pancreas tumors. The algorithm aims at generation of acceptable treatment plans, i.e., delivering the prescribed tumor dose while strictly obeying the imposed hard constraints for organs at risk and target. Extensions were made to minimize the beam number and/or to escalate the tumor dose. For 5 pancreas patients, the clinical value and the potential for beam number reduction and dose escalation were investigated. Comparisons were made with clinical plans and equiangular plans. Compared to clinical plans, the generated plans with the same number of beams yielded a substantial reduction in the dose to critical tissues. Using the algorithm, an escalated tumor dose of 58 Gy could be achieved for two cases. Maximum dose escalations required a minimum of 3 to 4 beam orientations. For 13 CT slices and an in-slice resolution of 0.5 cm, the total calculation times were 23-55 min, including precalculation of 180 input dose distributions (15 min). The algorithm yielded acceptable treatment plans with clinically feasible numbers of beams, even for escalated tumor doses. Generated plans were ...Continue Reading

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Citations

Dec 14, 2007·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Silvia MolinelliBen Heijmen
Oct 2, 2007·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jacco A de PooterBen J M Heijmen
Oct 3, 2006·International Journal of Radiation Oncology, Biology, Physics·Jacco A de PooterBen J M Heijmen
Dec 13, 2006·Medical Physics·Achim SchweikardJohn R Adler
Jan 30, 2019·The British Journal of Radiology·Gregory SmythJames L Bedford
Mar 28, 2008·Physics in Medicine and Biology·Evert WoudstraPascal R M Storchi
Aug 30, 2021·International Journal of Computer Assisted Radiology and Surgery·Ruijin ZhangGuobin Zhang

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