Automated Chemical Sensing Unit Integration for Parallel Optical Interrogation

Sensors
Ana L HernándezM Holgado

Abstract

We report the integration of an automated chemical optical sensing unit for the parallel interrogation of 12 BICELLs in a sensing chip. The work was accomplished under the European Project Enviguard (FP7-OCEAN-2013-614057) with the aim of demonstrating an optical nano-biosensing unit for the in-situ detection of various chemical pollutants simultaneously in oceanic waters. In this context, we designed an optical sensing chip based on resonant nanopillars (R-NPs) transducers organized in a layout of twelve biophotonic sensing cells (BICELLs). The sensing chip is interrogated in reflection with a 12-channels optical spectrometer equipped with an embedded computer-on-chip performing image processing for the simultaneous acquisition and analysis (resonant mode fitting) of the 12 spectra. A microfluidic chip and an automated flow control system composed of four pumps and a multi-path micro-valve makes it possible to drive different complex protocols. A rack was designed ad-hoc for the integration of all the modules. As a proof of concept, fluids of different refractive index (RI) were flowed in the system in order to measure the time response (sensogram) of the R-NPs under optical reflectance, and assess the sensors' bulk sensitivit...Continue Reading

References

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Citations

Feb 15, 2020·Analytical and Bioanalytical Chemistry·Rafael CasquelPedro Herreros
Oct 20, 2020·ACS Omega·Sergio QuinteroMiguel Holgado

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Methods Mentioned

BETA
biosensors
chips
chip
biosensor

Software Mentioned

Enviguard
RSoft

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