Automated concentration of [18 F]fluoride into microliter volumes

Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine
Philip H ChaoR Michael van Dam

Abstract

Concentration of [18F]fluoride has been mentioned in literature, however, reports have lacked details about system designs, operation, and performance. Here, we describe in detail a compact, fast, fully-automated concentration system based on a micro-sized strong anion exchange cartridge. The concentration of radionuclides enables scaled-up microfluidic synthesis. Our system can also be used to provide highly concentrated [18F]fluoride with minimal water content. We demonstrate how the concentrator can produce varying concentrations of [18F]fluoride for the macroscale synthesis of N-boc-5-[18F]fluoroindole without an azeotropic drying process, while enabling high starting radioactivity. By appropriate choice of solid-phase resin, flow conditions, and eluent solution, we believe this approach can be extended beyond [18F]fluoride to other radionuclides.

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Citations

Jun 13, 2019·Lab on a Chip·Jia WangR Michael van Dam
Dec 5, 2020·EJNMMI Radiopharmacy and Chemistry·Ksenia LisovaR Michael van Dam
Feb 1, 2020·Reaction Chemistry & Engineering·Jia WangR Michael van Dam

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