Automated data-adaptive analytics for electronic healthcare data to study causal treatment effects

Clinical Epidemiology
Sebastian Schneeweiss

Abstract

Decision makers in health care increasingly rely on nonrandomized database analyses to assess the effectiveness, safety, and value of medical products. Health care data scientists use data-adaptive approaches that automatically optimize confounding control to study causal treatment effects. This article summarizes relevant experiences and extensions. The literature was reviewed on the uses of high-dimensional propensity score (HDPS) and related approaches for health care database analyses, including methodological articles on their performance and improvement. Articles were grouped into applications, comparative performance studies, and statistical simulation experiments. The HDPS algorithm has been referenced frequently with a variety of clinical applications and data sources from around the world. The appeal of HDPS for database research rests in 1) its superior performance in situations of unobserved confounding through proxy adjustment, 2) its predictable efficiency in extracting confounding information from a given data source, 3) its ability to automate estimation of causal treatment effects to the extent achievable in a given data source, and 4) its independence of data source and coding system. Extensions of the HDPS ap...Continue Reading

Citations

Feb 16, 2019·Circulation. Cardiovascular Quality and Outcomes·Sebastian SchneeweissKrista F Huybrechts
Mar 7, 2019·European Journal of Epidemiology·Sebastian Schneeweiss
Apr 7, 2020·Diabetes, Obesity & Metabolism·Yoon Kong Loke, Katharina Mattishent
Dec 18, 2019·Clinical Pharmacology and Therapeutics·Alison CaveUNKNOWN HMA-EMA Joint Big Data Taskforce
Oct 8, 2020·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Andrew Bate, Steve F Hobbiger
Oct 12, 2020·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Sarah AhmadJordana B Cohen
Oct 19, 2019·Thérapie·Nicholas MooreCécile Droz
Mar 13, 2021·Endocrine Reviews·Sebastian Schneeweiss, Elisabetta Patorno
Dec 26, 2021·Pharmacoepidemiology and Drug Safety·Imane BenasseurJason R Guertin

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