Automated detection of brain metastases on non-enhanced CT using single-shot detectors.

Neuroradiology
Shimpei KatoOsamu Abe

Abstract

To develop and investigate deep learning-based detectors for brain metastases detection on non-enhanced (NE) CT. The study included 116 NECTs from 116 patients (81 men, age 66.5 ± 10.6 years) to train and test single-shot detector (SSD) models using 89 and 27 cases, respectively. The annotation was performed by three radiologists using bounding-boxes defined on contrast-enhanced CT (CECT) images. NECTs were coregistered and resliced to CECTs. The detection performance was evaluated at the SSD's 50% confidence threshold using sensitivity, positive-predictive value (PPV), and the false-positive rate per scan (FPR). For false negatives and true positives, binary logistic regression was used to examine the possible contributing factors. For lesions 6 mm or larger, the SSD achieved a sensitivity of 35.4% (95% confidence interval (CI): [32.3%, 33.5%]); 51/144) with an FPR of 14.9 (95% CI [12.4, 13.9]). The overall sensitivity was 23.8% (95% CI: [21.3%, 22.8%]; 55/231) and PPV was 19.1% (95% CI: [18.5%, 20.4%]; 98/ of 513), with an FPR of 15.4 (95% CI [12.9, 14.5]). Ninety-five percent of the lesions that SSD failed to detect were also undetectable to radiologists (168/176). Twenty-four percent of the lesions (13/50) detected by the S...Continue Reading

References

Jul 16, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jill S Barnholtz-SloanRaymond E Sawaya
May 30, 2013·Surgical Neurology International·Keith J Stelzer
Nov 15, 2013·Therapeutic Advances in Neurological Disorders·Dagny Holle, Mark Obermann
Jun 14, 2016·IEEE Transactions on Pattern Analysis and Machine Intelligence·Shaoqing RenJian Sun
Jul 10, 2017·Radiological Physics and Technology·Kenji Suzuki
Mar 7, 2018·Trends in Cancer·Manuel ValienteRiccardo Soffietti
Jan 23, 2019·International Journal of Computer Assisted Radiology and Surgery·Noha GhatwaryXujiong Ye
May 3, 2019·Journal of Magnetic Resonance Imaging : JMRI·Endre GrøvikGreg Zaharchuk
Oct 23, 2019·Proceedings of the National Academy of Sciences of the United States of America·Weicheng KuoEsther L Yuh
Nov 7, 2019·Journal of the American College of Radiology : JACR·UNKNOWN Expert Panel on Neurologic ImagingJulie Bykowski
Feb 8, 2020·Advances in Experimental Medicine and Biology·Heang-Ping ChanChuan Zhou
Mar 14, 2020·Journal of Magnetic Resonance Imaging : JMRI·Min ZhangXiaoyin Xu
Mar 24, 2020·IEEE Journal of Biomedical and Health Informatics·Engin DikiciLuciano M Prevedello

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