Automated diagnosis and segmentation of choroidal neovascularization in OCT angiography using deep learning

Biomedical Optics Express
Jie WangYali Jia

Abstract

Accurate identification and segmentation of choroidal neovascularization (CNV) is essential for the diagnosis and management of exudative age-related macular degeneration (AMD). Projection-resolved optical coherence tomographic angiography (PR-OCTA) enables both cross-sectional and en face visualization of CNV. However, CNV identification and segmentation remains difficult even with PR-OCTA due to the presence of residual artifacts. In this paper, a fully automated CNV diagnosis and segmentation algorithm using convolutional neural networks (CNNs) is described. This study used a clinical dataset, including both scans with and without CNV, and scans of eyes with different pathologies. Furthermore, no scans were excluded due to image quality. In testing, all CNV cases were diagnosed from non-CNV controls with 100% sensitivity and 95% specificity. The mean intersection over union of CNV membrane segmentation was as high as 0.88. By enabling fully automated categorization and segmentation, the proposed algorithm should offer benefits for CNV diagnosis, visualization monitoring.

References

Dec 22, 1998·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·M P López-SáezM L Baeza
Mar 12, 2004·American Journal of Ophthalmology·Hans E Grossniklaus, W Richard Green
Feb 28, 2006·Survey of Ophthalmology·Larry A DonosoGregory Hageman
Oct 6, 2006·The New England Journal of Medicine·Paulus T V M de Jong
Jun 14, 2008·The New England Journal of Medicine·Rama D JagerJoan W Miller
Apr 22, 2015·Proceedings of the National Academy of Sciences of the United States of America·Yali JiaDavid Huang
Jul 15, 2015·American Journal of Ophthalmology·Laura KuehleweinDavid Sarraf
Oct 3, 2015·Retina·Richard F SpaideNadia K Waheed
May 28, 2016·Biomedical Optics Express·Miao ZhangYali Jia
Jun 13, 2016·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·Chengzhang ZhuYixiong Liang
May 4, 2017·IEEE Transactions on Pattern Analysis and Machine Intelligence·Liang-Chieh ChenAlan L Yuille
Jun 4, 2017·International Journal of Computer Assisted Radiology and Surgery·Juan Mo, Lei Zhang
Aug 5, 2018·Progress in Retinal and Eye Research·Ursula Schmidt-ErfurthHrvoje Bogunović
Oct 4, 2018·Translational Vision Science & Technology·Alison D TreisterAmani A Fawzi
Oct 30, 2018·Investigative Ophthalmology & Visual Science·Rachel PatelYali Jia
Nov 22, 2018·Biomedical Optics Express·Yukun GuoYali Jia
Jul 2, 2019·PloS One·Stefan MaetschkeRahil Garnavi

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Citations

Jul 23, 2020·Current Opinion in Ophthalmology·Rebekah H GensureJohn P Campbell
Jul 9, 2020·Biomedical Optics Express·Cong WangDeyin Li
Oct 6, 2020·Biomedical Optics Express·Min GaoYali Jia
Aug 3, 2020·Ophthalmology and Therapy·Enrico BorrelliGiuseppe Querques
Mar 27, 2021·Progress in Retinal and Eye Research·Tristan T HormelYali Jia
Jun 25, 2021·Progress in Retinal and Eye Research·Ursula Schmidt-ErfurthHrvoje Bogunović
Jul 20, 2021·Experimental Biology and Medicine·David LeXincheng Yao

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