Automated diagnosis of fetal alcohol syndrome using 3D facial image analysis.

Orthodontics & Craniofacial Research
S FangCollaborative Initiative on Fetal Alcohol Spectrum Disorders

Abstract

Use three-dimensional (3D) facial laser scanned images from children with fetal alcohol syndrome (FAS) and controls to develop an automated diagnosis technique that can reliably and accurately identify individuals prenatally exposed to alcohol. A detailed dysmorphology evaluation, history of prenatal alcohol exposure, and 3D facial laser scans were obtained from 149 individuals (86 FAS; 63 Control) recruited from two study sites (Cape Town, South Africa and Helsinki, Finland). Computer graphics, machine learning, and pattern recognition techniques were used to automatically identify a set of facial features that best discriminated individuals with FAS from controls in each sample. An automated feature detection and analysis technique was developed and applied to the two study populations. A unique set of facial regions and features were identified for each population that accurately discriminated FAS and control faces without any human intervention. Our results demonstrate that computer algorithms can be used to automatically detect facial features that can discriminate FAS and control faces.

References

Jun 1, 1992·Archives of Disease in Childhood·I Autti-RämöM L Granström
Aug 28, 1991·JAMA : the Journal of the American Medical Association
Oct 1, 1990·American Journal of Diseases of Children·B B LittleN F Gant
Nov 3, 1973·Lancet·K L Jones, D W Smith
Dec 9, 2000·American Journal of Public Health·P A MayD Viljoen
Dec 2, 2004·Bioinformatics·Jianping HuaEdward R Dougherty
Dec 15, 2005·American Journal of Medical Genetics. Part a·Ilona Autti-RämöH Eugene Hoyme
May 11, 2006·Annals of Human Biology·Tania S Douglas, Denis L Viljoen
Nov 28, 2006·Drug and Alcohol Dependence·Philip A MayDenis L Viljoen

❮ Previous
Next ❯

Citations

Feb 27, 2013·Pediatrics·Michael SuttiePeter Hammond
Jan 27, 2010·American Journal of Medical Genetics. Part a·Tania S Douglas, Tinashe E M Mutsvangwa
Dec 17, 2009·American Journal of Medical Genetics. Part a·Tinashe E M MutsvangwaTania S Douglas
Apr 27, 2013·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Mirjam N LandgrafFlorian Heinen
Jan 24, 2015·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Sarah E Cavanaugh
Jun 14, 2017·Alcoholism, Clinical and Experimental Research·Michael SuttieUNKNOWN CIFASD
Jan 5, 2019·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Moritz Blanck-LubarschAriane Hohoff
Apr 11, 2018·BMJ Paediatrics Open·Tracey W TsangElizabeth J Elliott
Aug 8, 2020·Frontiers in Pediatrics·Laura AlmeidaMaría Dolores Gómez-Roig
Aug 29, 2021·Alcoholism, Clinical and Experimental Research·Melissa GrubbKaitlyn McLachlan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics
Chung How KauJ D English
Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons
Chung How KauFrank Hartles
European Journal of Orthodontics
R J Hennessy, J P Moss
© 2022 Meta ULC. All rights reserved