Automated Entire Thrombus Density Measurements for Robust and Comprehensive Thrombus Characterization in Patients with Acute Ischemic Stroke

PloS One
Emilie M M SantosMR CLEAN investigators

Abstract

In acute ischemic stroke (AIS) management, CT-based thrombus density has been associated with treatment success. However, currently used thrombus measurements are prone to inter-observer variability and oversimplify the heterogeneous thrombus composition. Our aim was first to introduce an automated method to assess the entire thrombus density and then to compare the measured entire thrombus density with respect to current standard manual measurements. In 135 AIS patients, the density distribution of the entire thrombus was determined. Density distributions were described using medians, interquartile ranges (IQR), kurtosis, and skewedness. Differences between the median of entire thrombus measurements and commonly applied manual measurements using 3 regions of interest were determined using linear regression. Density distributions varied considerably with medians ranging from 20.0 to 62.8 HU and IQRs ranging from 9.3 to 55.8 HU. The average median of the thrombus density distributions (43.5 ± 10.2 HU) was lower than the manual assessment (49.6 ± 8.0 HU) (p<0.05). The difference between manual measurements and median density of entire thrombus decreased with increasing density (r = 0.64; p<0.05), revealing relatively higher manua...Continue Reading

References

Mar 1, 1992·Stroke; a Journal of Cerebral Circulation·D LeysX Leclerc
Nov 5, 2005·Stroke; a Journal of Cerebral Circulation·Eung Yeop KimDong Ik Kim
May 3, 2008·Stroke; a Journal of Cerebral Circulation·Ozcan OzdemirDavid Pelz
Oct 7, 2009·Acta Neurologica Scandinavica·K Abul-KasimJ Petersson
Nov 20, 2009·IEEE Transactions on Medical Imaging·Stefan KleinJosien P W Pluim
Mar 12, 2011·Stroke; a Journal of Cerebral Circulation·David S LiebeskindJeffrey L Saver
Aug 4, 2011·Journal of Thrombosis and Haemostasis : JTH·L F BrassT J Stalker
Aug 31, 2011·Stroke Research and Treatment·P R FitzsimmonsR Durairaj
May 24, 2012·Journal of Neurointerventional Surgery·Michael T FroehlerUNKNOWN UCLA Stroke Investigators
Jun 23, 2012·Stroke; a Journal of Cerebral Circulation·Christian H RiedelOlav Jansen
Nov 1, 2012·Stroke; a Journal of Cerebral Circulation·Parham MoftakharSteven W Hetts
Jun 1, 2013·AJNR. American Journal of Neuroradiology·U YilmazP Papanagiotou
Jun 25, 2013·Neuroradiology·J M NiestenUNKNOWN DUtch acute Stroke Trial (DUST)
Dec 18, 2014·The New England Journal of Medicine·Olvert A BerkhemerUNKNOWN MR CLEAN Investigators

❮ Previous
Next ❯

Citations

Jan 13, 2018·Stroke; a Journal of Cerebral Circulation·Heitor C AlvesUNKNOWN MR CLEAN trial investigators
Oct 13, 2018·Journal of Stroke·Liang ShuUlf Jensen-Kondering

❮ Previous
Next ❯

Software Mentioned

Mevislab®
SPSS

Related Concepts

Related Feeds

Acute Stroke

A stroke occurs when blood supply to the brain is interrupted depriving the brain of oxygen and nutrients. This feed focuses cerebrovascular accidents including ischemic and paralytic stroke.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.