Automated evaluation of pharmaceutically active ionic liquids' (eco)toxicity through the inhibition of human carboxylesterase and Vibrio fischeri

Journal of Hazardous Materials
Susana P F CostaM Lúcia M F S Saraiva

Abstract

The toxicity of 16 pharmaceutical active ionic liquids (IL-APIs) was evaluated by automated approaches based on sequential injection analysis (SIA). The implemented bioassays were centered on the inhibition of human carboxylesterase 2 and Vibrio fischeri, in the presence of the tested compounds. The inhibitory effects were quantified by calculating the inhibitor concentration required to cause 50% of inhibition (EC50). The EC50 values demonstrated that the cetylpyridinium group was one of the most toxic cations and that the imidazolium group was the less toxic. The obtained results provide important information about the safety of the studied IL-APIs and their possible use as pharmaceutical drugs. The developed automated SIA methodologies are robust screening bioassays, and can be used as a generic tools to identify the (eco)toxicity of the structural elements of ILs, contributing to a sustainable development of drugs.

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Citations

Jan 26, 2016·Chemosphere·Yunchang FanChengcheng Pan
Nov 27, 2014·Proceedings of the National Academy of Sciences of the United States of America·Wei YanRen Xiang Tan
Jan 24, 2016·International Journal of Biological Macromolecules·Xing DongShaofeng Hua
Jan 27, 2017·Chemical Reviews·Ksenia S EgorovaValentine P Ananikov
Mar 20, 2015·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Maria AtanassovaIsabelle Billard
Jan 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Fátima A R MotaM Lúcia M F S Saraiva
May 12, 2021·The Science of the Total Environment·Chul-Woong ChoYeoung-Sang Yun
Aug 28, 2020·Ecotoxicology and Environmental Safety·Tian LanQiang Wang
Nov 24, 2021·Chemical Society Reviews·Penghao WeiBing Yan

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