Automated flow-through synthesis of heterocyclic thioethers

Journal of Combinatorial Chemistry
Daniel JönssonMark Ladlow

Abstract

The fully automated, sequential flow-through synthesis of a 44-member array of thioethers 10[1-4,1-11] employing a resin "capture and release" reactor column is described. The array incorporates four different heterocyclic scaffolds, and the synthesis was performed using a custom-built robotic synthesizer that is able to (i) load and regenerate the reactor column and (ii) array each product into a single vial using UV threshold detection. All the compounds were obtained in high yield (>75%) and excellent purity (>95%) without the need for further purification.

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Citations

Jan 1, 2008·Acta Crystallographica. Section E, Structure Reports Online·Bo-Nian LiuCheng Guo
Jan 1, 2008·Acta Crystallographica. Section E, Structure Reports Online·Hao-Yuan LiCheng Guo
Mar 15, 2006·Drug Discovery Today·Grant E BoldtKim D Janda
Apr 19, 2008·Organic & Biomolecular Chemistry·Marcus BaumannChristopher D Smith
Jun 16, 2007·Organic & Biomolecular Chemistry·Christopher D SmithSteven V Ley
Dec 16, 2017·Nature Reviews. Drug Discovery·Gisbert Schneider
Oct 21, 2010·Molecular Diversity·Marcus BaumannSteven V Ley
Mar 14, 2007·Journal of Combinatorial Chemistry·Charlotte M Griffiths-JonesMark Ladlow
Sep 13, 2005·Journal of Combinatorial Chemistry·Bimbisar Desai, C Oliver Kappe

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