Automated Greulich-Pyle bone age determination in children with chronic kidney disease

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Eva NüskenJörg Dötsch

Abstract

Growth restriction and retarded bone age are common findings in children with chronic kidney disease (CKD). We compared the automated BoneXpert™ method with the manual assessment of an X-ray of the non-dominant hand. In this retrospective multicenter study, 359 patients with CKD stages 2-5, aged 2-14.5 (girls) or 2.5-17 years (boys) were included. Bone age was determined manually by three experts (according to Greulich and Pyle). Automated determination of bone age was performed using the image analysis software BoneXpert™. There was a strong correlation between the automatic and the manual method (r = 0.983, p < 0.001). The automatic method tended to generate higher bone age values (0.64 ± 0.73 years) in the younger patients (4-5 years) and to underestimate retardation or acceleration of bone age. The so-called "bone health index" (BHI) was reduced in comparison to the reference population. Bone health index standard deviation score (BHI-SDS) was not related to the stage of CKD, but weakly negatively correlated with plasma PTH concentrations (r = 0.12, p = 0.019). BoneXpert™ allows an objective, time-saving, and in general valid bone age assessment in children with CKD. Possible underestimation of retarded or accelerated bone ...Continue Reading

References

Jul 1, 1990·Pediatric Research·F SchaeferK Schärer
Nov 1, 1971·American Journal of Physical Anthropology·E Andersen
Jan 1, 2009·IEEE Transactions on Medical Imaging·Hans Henrik ThodbergKaren Damgaard Pedersen
Jan 7, 2009·Pediatric Radiology·Rick R van RijnHans Henrik Thodberg
Nov 26, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·H H ThodbergS Kreiborg
Apr 15, 2010·Hormone Research in Pædiatrics·David D MartinToshiaki Tanaka
Apr 17, 2010·Hormone Research in Pædiatrics·David D MartinHans Henrik Thodberg
Feb 9, 2012·Journal of Pediatric Endocrinology & Metabolism : JPEM·David D MartinGerhard Binder
Oct 4, 2012·Kidney International·Anne TsampalierosMary B Leonard
Mar 8, 2013·Seminars in Nephrology·Katherine Wesseling-Perry, Isidro B Salusky
Jun 27, 2013·Kidney International·Ranjani N Moorthi, Sharon M Moe
Oct 1, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·John WagnerSteven Fishbane

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Citations

Apr 12, 2015·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Saritha Ranabothu, Frederick J Kaskel
Dec 21, 2018·American Journal of Medical Genetics. Part a·Ken SaidaNaomichi Matsumoto
Nov 28, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sevcan A BakkalogluUNKNOWN European Society for Paediatric Nephrology (ESPN) Chronic Kidney Disease Mineral and Bone Disorder (CKD-MBD) and Dialysis wo
Dec 19, 2020·RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin·Vera DieteDaniel Vogele

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