Automated image analysis method for quantifying damage accumulation in tendon.

Journal of Biomechanics
Jedd B SereyskyEvan L Flatow

Abstract

Tendon pathology is frequently sub-clinical prior to frank rupture, denoting the need for non-destructive methods of assessing disease presence and progression. Despite the lack of clinical presentation, previous studies have observed that distinct changes to the tendon microstructure are present, and that such qualitative changes have a dose-response relationship with the level of damage accumulated. These initial findings suggest that there is value in investigating the physical nature of damage within tendon, not only to better understand the pathological process, but also to gain insight into reparative processes and develop treatments. However, a necessary first step towards carrying out these avenues of research is to develop diagnostic tools for quantitatively assessing the level of damage present. In this study, we established a dose-response relationship between a quantitative measure of structural damage and the level of global damage induced. Furthermore, we developed and validated an automated technique for quantifying matrix disorganization (damage), which correlates and co-localizes strongly with manual quantification. In combination, these findings allow us to measure the amount of damage accumulation of a region...Continue Reading

References

Oct 31, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·L TsorefG Navon
Dec 25, 2008·Journal of the Royal Society, Interface·P Ciarletta, M Ben Amar

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Citations

Nov 28, 2013·Journal of Biomechanics·Benjamin R FreedmanLouis J Soslowsky
Mar 17, 2015·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Benjamin R FreedmanLouis J Soslowsky
Mar 4, 2015·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·R BellN Andarawis-Puri
Nov 11, 2011·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Jedd B SereyskyEvan L Flatow
Dec 21, 2012·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Samuel P VeresJ Michael Lee
Jun 19, 2013·International Journal of Experimental Pathology·Jedd B SereyskyNelly Andarawis-Puri
Apr 25, 2016·Journal of the Mechanical Behavior of Biomedical Materials·Hanifeh KhayyeriHanna Isaksson
Oct 8, 2013·Journal of Biomechanics·Pat McLaughlin
May 14, 2016·Biology Open·Benjamin K RobinsonArmando Del Río Hernández
Jul 20, 2018·Scientific Reports·Benjamin R FreedmanLouis J Soslowsky
Feb 23, 2018·Journal of the Royal Society, Interface·Benjamin R FreedmanLouis J Soslowsky
Oct 18, 2018·Journal of Biomaterials Applications·Jianming Li, Wen Gao
Nov 13, 2017·ACS Biomaterials Science & Engineering·Sheng-Lin LeeChen-Yuan Dong

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