Automated mapping and N-Staging of thoracic lymph nodes in contrast-enhanced CT scans of the chest using a fully convolutional neural network.

European Journal of Radiology
Andra-Iza IugaThorsten Persigehl

Abstract

To develop a deep-learning (DL)-based approach for thoracic lymph node (LN) mapping based on their anatomical location. The training-and validation-dataset included 89 contrast-enhanced computed tomography (CT) scans of the chest. 4201 LNs were semi-automatically segmented and then assigned to LN levels according to their anatomical location. The LN level classification task was addressed by a multi-class segmentation procedure using a fully convolutional neural network. Mapping was performed by firstly determining potential level affiliation for each voxel and then performing majority voting over all voxels belonging to each LN. Mean classification accuracies on the validation data were calculated separately for each level and overall Top-1, Top-2 and Top-3 scores were determined, where a Top-X score describes how often the annotated class was within the top-X predictions. To demonstrate the clinical applicability of our model, we tested its N-staging capabilities in a simulated clinical use case scenario assuming a patient diseased with lung cancer. The artificial intelligence(AI)-based assignment revealed mean classification accuracies of 86.36 % (Top-1), 94.48 % (Top-2) and 96.10 % (Top-3). Best accuracies were achieved for...Continue Reading

References

Nov 1, 1989·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·T A ListerM Tubiana
Jun 1, 1997·Chest·C F Mountain, C M Dresler
Dec 19, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·L H SchwartzE A Eisenhauer
Feb 25, 2010·Annals of Surgical Oncology·Stephen B Edge, Carolyn C Compton
Mar 2, 2011·International Journal of Computer Assisted Radiology and Surgery·Kongkuo LuWilliam E Higgins
Sep 14, 2018·Quantitative Imaging in Medicine and Surgery·Wanyin LimSaeed Mirsadraee

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