PMID: 9557784Apr 29, 1998Paper

Automated measurement of melanoma cross-sectional area

The American Journal of Dermatopathology
J SmolleH Kerl

Abstract

The object of this study was to evaluate the prognostic impact of a cross-sectional area measured in routinely stained slides of cutaneous melanoma using fully automated image analysis. Hematoxylin-eosin stained slides of 238 specimens of primary cutaneous melanoma with Clark levels III to V were evaluated by digital image analysis using color video images, a scanning stage, and autofocus equipment. The cross-sectional area was significantly related to metastasis-free survival. Lesions with a cross-sectional area < or = 12 mm2 showed a 2-year metastasis-free survival rate of 92+/-2% compared with 41+/-8% in lesions with a cross-sectional area > 12 mm2 (log rank test: z = 71, p < 0.0001). The same was true for overall survival (98+/-1% compared with 82+/-6%; z = 42.12, p < 0.0001). In multivariate analysis, the cross-sectional area seems to provide prognostic information in addition to that provided by Breslow's index. In cases with regression and in small melanomas with vertical growth, however, metastatic spread may occur in lesions with a small cross-sectional area. It was concluded that automated measurement of the cross-sectional area may be helpful in assessing prognosis in cutaneous melanoma.

References

Dec 20, 1989·Journal of the National Cancer Institute·W H ClarkA C Halpern
May 1, 1989·Statistics in Medicine·M R Segal, D A Bloch
Mar 1, 1989·The American Journal of Surgical Pathology·M E Fallowfield, M G Cook
Jan 1, 1974·International Journal of Aging & Human Development·E F Pascarelli, W Fischer
Jun 1, 1983·Journal of the American Academy of Dermatology·J C Maize
Sep 1, 1982·The Journal of Dermatologic Surgery and Oncology·A W KopfA H Postel
Feb 1, 1993·American Journal of Surgery·L A PontikesL H Marx

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Citations

Dec 20, 2008·Clinics in Dermatology·Michael J PayetteJane M Grant-Kels
Jul 22, 2017·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Brooke E RosenbaumNooshin Brinster

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