Automated model-based quantitative analysis of phantoms with spherical inserts in FDG PET scans

Medical Physics
Ethan J UlrichReinhard R Beichel

Abstract

Quality control plays an increasingly important role in quantitative PET imaging and is typically performed using phantoms. The purpose of this work was to develop and validate a fully automated analysis method for two common PET/CT quality assurance phantoms: the NEMA NU-2 IQ and SNMMI/CTN oncology phantom. The algorithm was designed to only utilize the PET scan to enable the analysis of phantoms with thin-walled inserts. We introduce a model-based method for automated analysis of phantoms with spherical inserts. Models are first constructed for each type of phantom to be analyzed. A robust insert detection algorithm uses the model to locate all inserts inside the phantom. First, candidates for inserts are detected using a scale-space detection approach. Second, candidates are given an initial label using a score-based optimization algorithm. Third, a robust model fitting step aligns the phantom model to the initial labeling and fixes incorrect labels. Finally, the detected insert locations are refined and measurements are taken for each insert and several background regions. In addition, an approach for automated selection of NEMA and CTN phantom models is presented. The method was evaluated on a diverse set of 15 NEMA and 20...Continue Reading

References

Jun 24, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Lioe-Fee de Geus-OeiWim J G Oyen
Jun 24, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Richard L WahlMartin A Lodge
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Nov 17, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Ronald BoellaardBernd J Krause
Jul 10, 2012·Magnetic Resonance Imaging·Andriy FedorovRon Kikinis
Apr 9, 2013·European Journal of Nuclear Medicine and Molecular Imaging·Charline LasnonNicolas Aide
Dec 20, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·John J Sunderland, Paul E Christian
Feb 20, 2016·Journal of Applied Clinical Medical Physics·Larry A PiercePaul E Kinahan

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Citations

Apr 26, 2019·Journal of Nuclear Medicine Technology·Frank P DiFilippoSagar Patel
Mar 22, 2020·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Suleman SurtiJoel S Karp

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