Automated MRI analysis for identification of hippocampal atrophy in temporal lobe epilepsy

Epilepsia
Leonardo BonilhaMark A Eckert

Abstract

Hippocampal sclerosis is frequently associated with hippocampal atrophy (HA), which is often observed on routine magnetic resonance imaging (MRI) of patients with medial temporal lobe epilepsy (MTLE). Manual morphometry of the hippocampus is sensitive to detecting HA, but is time-consuming and prone to operator error. Automated MRI morphometry has the potential to provide rapid and accurate assistance in the clinical detection of HA. We performed a voxel-based morphometry analysis of 23 consecutive subjects with MTLE and 58 matched controls. Images from randomly selected 34 controls were used to create mean and standard deviation images of gray matter volume. Voxel-wise standardized Z-score hippocampal images from patients and the remaining 24 controls were cross-checked with receiver operating characteristic (ROC) curves to evaluate sensitivity versus one-specificity rate for a binary classifier (atrophied versus normal hippocampi). The ipsilateral hippocampi of patients with MTLE displayed a significantly lower mean Z-score compared to the hippocampi of controls [F(2,67) = 33.014, p < 0.001, Tukey HSD < 0.001]. A classifier using the hippocampal gray matter Z-scores to discriminate between atrophied and normal hippocampi yiel...Continue Reading

Citations

Sep 16, 2010·Nature Reviews. Neurology·John S Duncan
Nov 5, 2011·Epilepsia·Leonardo BonilhaJonathan C Edwards
Jan 1, 2011·Epilepsy Research and Treatment·Kristen M Kelly, Steve S Chung
Jun 19, 2014·BMC Neurology·Hila GoldbergRobert Zivadinov
Feb 27, 2010·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Mark Richardson
Sep 13, 2015·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Petros StylianouSagi Harnof
Aug 13, 2011·NeuroImage·Niels K FockeJohn S Duncan
Jan 20, 2015·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·R VastaA Gambardella
May 6, 2016·Frontiers in Neuroscience·Stefano TrebeschiAlexander Valentinitsch
Aug 30, 2011·Epilepsy Research·Hans-Jürgen HuppertzHorst Urbach
Aug 3, 2013·Korean journal of pediatrics·Yun-Jin Lee, Joon Soo Lee
Jun 12, 2020·AJNR. American Journal of Neuroradiology·F RiedererC Baumgartner

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