Automated neuromelanin imaging as a diagnostic biomarker for Parkinson's disease

Movement Disorders : Official Journal of the Movement Disorder Society
Gabriel CastellanosMaría A Pastor

Abstract

We aimed to analyze the diagnostic accuracy of an automated segmentation and quantification method of the SNc and locus coeruleus (LC) volumes based on neuromelanin (NM)-sensitive MRI (NM-MRI) in patients with idiopathic (iPD) and monogenic (iPD) Parkinson's disease (PD). Thirty-six patients (23 idiopathic and 13 monogenic PARKIN or LRRK2 mutations) and 37 age-matched healthy controls underwent 3T-NM-MRI. SNc and LC volumetry were performed using fully automated multi-image atlas segmentation. The diagnostic performance to differentiate PD from controls was measured using the area under the curve (AUC) and likelihood ratios based on receiver operating characteristic (ROC) analyses. We found a significant reduction of SNc and LC volumes in patients, when compared to controls. ROC analysis showed better diagnostic accuracy when using SNc volume than LC volume. Significant differences between ipsilateral and contralateral SNc volumes, in relation to the more clinically affected side, were found in patients with iPD (P = 0.007). Contralateral atrophy in the SNc showed the highest power to discriminate PD subjects from controls (AUC, 0.93-0.94; sensitivity, 91%-92%; specificity, 89%; positive likelihood ratio: 8.4-8.5; negative like...Continue Reading

References

Oct 1, 1978·Seminars in Nuclear Medicine·C E Metz
Nov 1, 1992·Annals of Neurology·D C GermanD M Mann
Mar 1, 1992·Journal of Neurology, Neurosurgery, and Psychiatry·A J HughesA J Lees
Oct 1, 1989·Annals of Neurology·D C GermanC B Saper
Mar 26, 2002·Brain : a Journal of Neurology·Andrew J HughesAndrew J Lees
Apr 27, 2005·Lancet·David A Grimes, Kenneth F Schulz
Jul 8, 2005·Brain : a Journal of Neurology·Glenda M HallidayKay L Double
Aug 18, 2006·Lancet Neurology·Ruth DjaldettiEldad Melamed
Jan 2, 2009·Movement Disorders : Official Journal of the Movement Disorder Society·Vicky L MarshallDonald G Grosset
Feb 21, 2009·IEEE Transactions on Medical Imaging·Xabier ArtaechevarriaCarlos Ortiz-de-Solorzano
Apr 2, 2010·Brain : a Journal of Neurology·Lluís SamaranchPau Pastor
Jun 15, 2010·Journal of Neurology, Neurosurgery, and Psychiatry·Simone van de LooDaniela Berg
Jan 12, 2011·Archives of Neurology·Yuncheng WuJoseph Jankovic
Apr 15, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Stefan T SchwarzDorothee P Auer
May 28, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Guangwei DuXuemei Huang
Jul 2, 2011·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Kenichi KashiharaFumiyo Higaki
Nov 15, 2011·Brain : a Journal of Neurology·Ramachandiran NandhagopalA Jon Stoessl
Mar 28, 2012·Movement Disorders : Official Journal of the Movement Disorder Society·Markos PoulopoulosRoy N Alcalay
Jun 1, 2012·Movement Disorders : Official Journal of the Movement Disorder Society·Stéphane LehéricyCecile Gallea
Mar 6, 2013·JAMA Neurology·Karen M DohertyJanice L Holton
Apr 16, 2013·Academic Radiology·Kelly H ZouJavier Cabrera
May 16, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Janey ProdoehlDavid E Vaillancourt
Jun 26, 2013·European Neurology·Keita MatsuuraHidekazu Tomimoto
Jun 27, 2013·Brain : a Journal of Neurology·Daniel García-LorenzoStéphane Lehericy
Jul 26, 2013·Brain : a Journal of Neurology·Jeffrey H KordowerRaymond T Bartus
Aug 13, 2013·PloS One·Alisdair McNeillAnthony H V Schapira
Apr 29, 2014·Parkinsonism & Related Disorders·Chigumi OhtsukaYasuo Terayama
Oct 14, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Stéphane LehéricyChantal François

❮ Previous
Next ❯

Citations

Feb 2, 2016·Expert Review of Neurotherapeutics·Musleh A Algarni, A Jon Stoessl
Sep 7, 2016·Frontiers in Aging Neuroscience·Ioannis U IsaiasAntonella Costa
Jan 15, 2016·Translational Research : the Journal of Laboratory and Clinical Medicine·Paul Tuite
Dec 10, 2016·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Karra D HarringtonUNKNOWN AIBL Research Group
Apr 6, 2017·Journal of Neural Transmission·Beatrice HeimKlaus Seppi
Apr 4, 2017·Movement Disorders : Official Journal of the Movement Disorder Society·Stéphane LehericyUNKNOWN International Parkinson and Movement Disorder Society (IPMDS)-Neuroimaging Study Group
Nov 16, 2016·NeuroImage. Clinical·Tarja Lönnfors-WeitzelRoland Wiest
Jul 8, 2017·Movement Disorders : Official Journal of the Movement Disorder Society·Leonor Correia GuedesJoaquim J Ferreira
Feb 10, 2016·Journal of Chemical Neuroanatomy·YuHong FuGlenda M Halliday
May 4, 2017·The International Journal of Neuroscience·Antonio Martin-BastidaPaola Piccini
Jan 18, 2018·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·S PrasadP K Pal
Mar 10, 2018·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·J WangL Jin
Aug 6, 2017·European Radiology·Albert StezinPramod Kumar Pal
Sep 4, 2017·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Sara PietracupaPaola Piccini
Jun 17, 2020·Radiology·Paolo VitaliClaudia A M Gandini Wheeler-Kingshott
Aug 29, 2020·Brain : a Journal of Neurology·Emma BiondettiStéphane Lehéricy
Apr 1, 2017·Translational Neurodegeneration·Usman SaeedMario Masellis
Mar 31, 2016·Human Brain Mapping·Jason LangleyXiaoping Hu
May 30, 2017·Rinshō shinkeigaku = Clinical neurology·Satoshi Orimo
Oct 27, 2018·Movement Disorders Clinical Practice·Nicola Pavese, Yen F Tai
Apr 21, 2020·Frontiers in Neurology·Christopher M Laine, Francisco J Valero-Cuevas
Jul 4, 2017·Journal of Parkinson's Disease·Margherita FabbriJoaquim J Ferreira
Jun 30, 2018·AJNR. American Journal of Neuroradiology·N PyatigorskayaS Lehéricy
May 15, 2018·Movement Disorders : Official Journal of the Movement Disorder Society·Daisuke TaniguchiNobutaka Hattori
Jun 14, 2019·Frontiers in Aging Neuroscience·Kiarash GhassabanEwart Mark Haacke
May 6, 2019·Brain : a Journal of Neurology·Antonio Martín-BastidaPaola Piccini
Apr 24, 2020·Frontiers in Pharmacology·Elena Paredes-RodriguezCristina Miguelez
Sep 10, 2017·Movement Disorders : Official Journal of the Movement Disorder Society·J A ObesoA J Stoessl
Aug 9, 2019·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Xiangming WangLing Yang
Aug 28, 2020·Frontiers in Neurology·Germain ArribaratPatrice Péran
Feb 6, 2017·Journal of Neural Transmission·Taku HatanoNobutaka Hattori
May 17, 2018·Frontiers in Aging Neuroscience·Andrew C Peterson, Chiang-Shan R Li
Aug 19, 2018·Scientific Reports·Oleg SolopchukAlexandre Zénon

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.