Automated outbreak detection of hospital-associated pathogens: Value to infection prevention programs.

Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America
Meghan A BakerCDC Prevention Epicenters Program

Abstract

To assess the utility of an automated, statistically-based outbreak detection system to identify clusters of hospital-acquired microorganisms. Multicenter retrospective cohort study. The study included 43 hospitals using a common infection prevention surveillance system. A space-time permutation scan statistic was applied to hospital microbiology, admission, discharge, and transfer data to identify clustering of microorganisms within hospital locations and services. Infection preventionists were asked to rate the importance of each cluster. A convenience sample of 10 hospitals also provided information about clusters previously identified through their usual surveillance methods. We identified 230 clusters in 43 hospitals involving Gram-positive and -negative bacteria and fungi. Half of the clusters progressed after initial detection, suggesting that early detection could trigger interventions to curtail further spread. Infection preventionists reported that they would have wanted to be alerted about 81% of these clusters. Factors associated with clusters judged to be moderately or highly concerning included high statistical significance, large size, and clusters involving Clostridioides difficile or multidrug-resistant organis...Continue Reading

References

Jan 1, 1997·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J M Stelling, T F O'Brien
Sep 16, 1998·American Journal of Public Health·M KulldorffC R Key
Feb 19, 2005·PLoS Medicine·Martin KulldorffFarzad Mostashari
Mar 22, 2016·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Meghan A BakerDeborah S Yokoe
Sep 21, 2016·Emerging Infectious Diseases·Sharon K GreeneMartin Kulldorff
Mar 24, 2017·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Alessandra NataleFortunato D'Ancona
Jul 25, 2018·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Alicia ShugartAlexander J Kallen

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Citations

Nov 3, 2020·Expert Review of Anti-infective Therapy·John StellingThomas F O'Brien
Aug 10, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Meghan A BakerUNKNOWN CDC Prevention Epicenters Program

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