Automated oxygen flow titration to maintain constant oxygenation

Respiratory Care
François Lellouche, Erwan L'her

Abstract

One century after the introduction of the oxygen flow meter into clinical practice, we have developed a device, FreeO(2), that automatically titrates the oxygen flow delivered to spontaneously breathing patients, with the aim of maintaining a stable S(pO(2)). We evaluated this system in healthy subjects during induced hypoxemia. Hypoxemia was induced in 10 healthy subjects while breathing a gas mixture of variable F(IO(2)) (air + nitrogen). Each subject performed 3 hypoxemic challenges with the addition, in a random order, of either: air with constant flow (1.5 L/min); oxygen with constant flow (1.5 L/min); or automatic oxygen flow titration. Subjects were blinded to the intervention. Oxygen flow, S(pO(2)), end-tidal CO(2), respiratory rate, and heart rate were recorded every second. The primary outcome was the time with S(pO(2)) between 92% and 96%. The S(pO(2)) target (92-96%) was achieved a median of 26.0%, 36.8%, and 66.5% (P < .001) of the time with air, constant oxygen, and automated oxygen titration, respectively. Severe oxygen desaturations (S(pO(2)) < 88%) were respectively observed at a median of 33.7%, 12.7%, and 0.4% of the time (P < .001). Hyperoxia was present a median of 4.1%, 39.1%, and 14.5% of the time (P < .0...Continue Reading

Citations

May 25, 2016·SpringerPlus·Khawla AlzoubiOmar M Ramahi
Feb 21, 2014·Critical Care : the Official Journal of the Critical Care Forum·Kaouther SaihiLaurent Brochard
Jun 13, 2016·JACC. Heart Failure·Nariman Sepehrvand, Justin A Ezekowitz
Jul 22, 2017·The European Respiratory Journal·João Carlos Winck
Jul 22, 2017·The European Respiratory Journal·Erwan L'HerFrançois Lellouche
Oct 28, 2019·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Marie-Hélène DenaultFrançois Lellouche
Feb 26, 2020·Sensors·Daniel Sanchez-MorilloAntonio Leon-Jimenez
May 19, 2019·ESC Heart Failure·Nariman SepehrvandJustin A Ezekowitz
Dec 24, 2017·Expert Review of Clinical Pharmacology·Andrea S MelaniPaola Rottoli
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Mar 17, 2018·American Journal of Respiratory and Critical Care Medicine·Yves LacasseJerry A Krishnan
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